Resolving the kinetics of lipid, protein and peptide diffusion in membranes

Molecular Membrane Biology
John M Sanderson

Abstract

Recent developments in the understanding of molecular diffusion phenomena in membranes are reviewed. Both model bilayers and biological membranes are considered in respect of lateral diffusion, rotational diffusion and transverse diffusion (flip-flop). For model systems, particular attention is paid to recent data obtained using surface-specific techniques such as sum frequency generation vibrational spectroscopy on supported lipid bilayers, and fluorescence correlation spectroscopy on giant unilamellar vesicles, both of which have yielded new insights into the intrinsic rates of diffusion and the energetic barriers to processes such as lipid flip-flop. Advances in single-molecule and many-molecule fluorescence methodologies have enabled the observation of processes such as anomalous diffusion for some membrane species in biological membranes. These are discussed in terms of new models for the role of membrane interactions with the cytoskeleton, the effects of molecular crowding in membranes, and the formation of lipid rafts. The diffusion of peptides, proteins and lipids is considered, particularly in relation to the means by which antimicrobial peptide activity may be rationalized in terms of membrane poration and lipid flip-...Continue Reading

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Citations

Feb 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaojun ShiAdam W Smith
Jan 3, 2016·Chemistry and Physics of Lipids·Celia de la Calle ArreguiJohn M Sanderson
Jul 23, 2013·Journal of Molecular Biology·Robert H DodsJohn M Sanderson
Feb 16, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Eric S FriedM Lane Gilchrist
Dec 13, 2018·Physical Chemistry Chemical Physics : PCCP·Hannah M BrittJohn M Sanderson
Dec 12, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adam E Cohen, Zheng Shi
Mar 30, 2018·Current Opinion in Structural Biology·Charles R Sanders, James M Hutchison
Mar 25, 2021·Macromolecular Bioscience·Jiafang PiaoYuanchen Dong
May 5, 2020·The Journal of Physical Chemistry Letters·Jennifer C FlanaganCarlos R Baiz
Mar 1, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Ariane PeyretSébastien Lecommandoux
Nov 8, 2014·The Journal of Physical Chemistry. B·Michelle K Baker, Cameron F Abrams
Oct 13, 2021·Chemical Society Reviews·Shukun TangQun Wang

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