Resonance Raman measurement of macular carotenoids in the living human eye

Archives of Biochemistry and Biophysics
Paul S BernsteinWerner Gellermann

Abstract

There is growing evidence that high levels of the macular xanthophyll carotenoids lutein and zeaxanthin may be protective against visual loss from age-related macular degeneration. To study this protective effect further, it is important to measure macular carotenoid levels noninvasively in a wide variety of subjects. We have developed and validated resonance Raman spectroscopy as a sensitive and specific objective method to measure macular carotenoid levels in the living human eye. In this minireview, the principles and implementation of ocular carotenoid resonance Raman spectroscopy are reviewed, and the results of observational cross-sectional studies and of prospective supplementation studies on subjects with and without macular pathology are summarized. We have recently extended this technology to an imaging mode which will further enhance our understanding of the roles of lutein and zeaxanthin in normal macular function and in the prevention of age-related visual loss.

References


❮ Previous
Next ❯

Citations

Apr 28, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M TrieschmannD Pauleikhoff
Jan 12, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olivia HowellsHannah Bartlett
Dec 17, 2008·Journal of Ocular Biology, Diseases, and Informatics·Matthew S WardPaul S Bernstein
Mar 21, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shan-Yang LinShun-Li Wang
Feb 23, 2012·Journal of Biomedical Optics·Nicole J Crane, Eric A Elster
May 9, 2013·Investigative Ophthalmology & Visual Science·Paul S BernsteinWerner Gellermann
Jul 12, 2012·Nutritional Neuroscience·Rohini VishwanathanElizabeth J Johnson
Apr 23, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bogdana KomarJens Dawczynski
Nov 19, 2005·Journal of Biomedical Optics·Billy R Hammond, Billy R Wooten
Jan 18, 2006·Journal of Biomedical Optics·Igor V ErmakovW Gellermann
Jan 11, 2007·Journal of Biomedical Optics·Jan van de KraatsDirk van Norren
Nov 14, 2015·Foods·John W ErdmanMartha Neuringer
Jan 23, 2016·Journal of Ophthalmology·Joan E Roberts, Jessica Dennison
Apr 26, 2008·Optometry : Journal of the American Optometric Association·Ivan Y-F Leung
Nov 7, 2006·Experimental Eye Research·John M NolanStephen Beatty
May 2, 2008·Annals of the New York Academy of Sciences·Anna M PawlakAlan W Stitt
Jul 16, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Hannah BartlettFrank Eperjesi
Jul 19, 2005·Experimental Eye Research·Tos T J M Berendschot, Dirk van Norren
May 11, 2016·Cutaneous and Ocular Toxicology·Eswar Kumar Kilari, Swathi Putta
Jul 13, 2017·Journal of Biophotonics·Marco LombardoGiuseppe Lombardo
May 2, 2007·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·R E HoggR S Anderson
Apr 15, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Werner Gellermann, Paul S Bernstein
May 3, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Shelby E TempleGary P Misson
Dec 9, 2010·The Journal of Bone and Joint Surgery. American Volume·Benjamin K PotterEric A Elster
Jun 15, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Josephine V GlennAlan W Stitt
Sep 21, 2006·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Mohsen SharifzadehWerner Gellermann
Oct 26, 2018·Investigative Ophthalmology & Visual Science·Christine A Curcio
Aug 31, 2019·Biomedical Optics Express·Dimitrios ChristarasPablo Artal
Apr 1, 2010·Cancer Prevention Research·Brandon G BentzFrank A Fitzpatrick
Apr 6, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Haohao GuanZufang Huang
May 1, 2009·Biochemistry·Prakash BhosalePaul S Bernstein
Aug 11, 2021·Nutrients·Drake W LemPinakin Gunvant Davey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Werner GellermannPaul S Bernstein
Journal of Biomedical Optics
Igor V ErmakovPaul S Bernstein
© 2021 Meta ULC. All rights reserved