Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography.

Physics in Medicine and Biology
Amy L Oldenburg, Stephen A Boppart

Abstract

We present a new method for performing dynamic elastography of soft tissue samples. By sensing nanoscale displacements with optical coherence tomography, a chirped, modulated force is applied to acquire the mechanical spectrum of a tissue sample within a few seconds. This modulated force is applied via magnetic nanoparticles, named 'nanotransducers', which are diffused into the tissue, and which contribute negligible inertia to the soft tissue mechanical system. Using this novel system, we observed that excised tissues exhibit mechanical resonance modes which are well described by a linear damped harmonic oscillator. Results are validated by using cylindrical tissue phantoms of agarose in which resonant frequencies (30-400 Hz) are consistent with longitudinal modes and the sample boundary conditions. We furthermore show that the Young's modulus can be computed from their measured resonance frequencies, analogous to resonant ultrasound spectroscopy for stiff material analysis. Using this new technique, named magnetomotive resonant acoustic spectroscopy (MRAS), we monitored the relative stiffening of an excised rat liver during a chemical fixation process.

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Citations

May 8, 2013·Annals of Biomedical Engineering·Gongting WuAmy L Oldenburg
Nov 25, 2011·Journal of Biomedical Optics·Shiguang LiAmy L Oldenburg
Oct 3, 2013·Applied Physics Letters·Wenjuan QiZhongping Chen
Aug 3, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jongsik KimStephen A Boppart
May 3, 2011·Journal of Biomedical Optics·Cuiru SunVictor X D Yang
Apr 13, 2011·International Journal of Medical Informatics·A RamadasB Oldenburg
Jul 21, 2011·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Amy L OldenburgThomas H Fischer
Nov 21, 2014·Journal of Biophotonics·Shang Wang, Kirill V Larin
Aug 4, 2015·The Review of Scientific Instruments·C R KrebsAmy L Oldenburg
Jul 19, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Amy L OldenburgJustin M Sierchio
Oct 1, 2010·Journal of Innovative Optical Health Sciences·Xing LiangStephen A Boppart
Mar 9, 2017·Biomedical Optics Express·Kirill V Larin, David D Sampson
Sep 14, 2016·Journal of Biomedical Optics·Chen WuKirill V Larin
Aug 28, 2010·Physics in Medicine and Biology·Alex GrimwoodQuentin A Pankhurst
Dec 18, 2010·Optics Express·Steven G AdieStephen A Boppart
Feb 27, 2015·Physics in Medicine and Biology·Philip WijesingheBrendan F Kennedy
Jul 30, 2014·Biomedical Optics Express·Adeel AhmadStephen A Boppart
Aug 14, 2015·Physics in Medicine and Biology·Adeel AhmadStephen A Boppart
Jan 6, 2018·Optica·Francisco E RoblesWarren S Warren
Oct 1, 2019·Optics Letters·Yuechuan LinSteven G Adie
Dec 5, 2014·Journal of Biomedical Optics·Adeel AhmadStephen A Boppart

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