PMID: 2771885Jul 1, 1989Paper

Resorbed co-twin as an explanation for discrepant chorionic villus results: non-mosaic 47,XX,+16 in villi (direct and culture) with normal (46,XX) amniotic fluid and neonatal blood

Prenatal Diagnosis
A T TharapelJ L Simpson

Abstract

Non-mosaic trisomy 16 was observed in chorionic villus cytotrophoblasts (direct) as well as cultured mesenchymal core cells derived from the pregnancy of a 38-year-old woman. Chromosome preparations from amniotic fluid and neonatal cultures (cord blood) were 46,XX. Normal fetal growth as determined by serial ultrasound examinations occurred throughout the pregnancy, which resulted in a healthy 2724 g female. Multiple biopsies taken from the umbilical cord, placental cotyledons, and fetal membranes were 46,XX. However, a placental nodule and three of six cultures initiated from membranes (amnion and chorion) showed 46,XX/47,XX,+16 mosaicism. We propose that the trisomy 16 cells arose from residual villi derived from a trisomic co-twin that never developed. This case further demonstrates that normal fetal growth may presage normal outcome irrespective of cytogenetic findings in cytotrophoblasts (direct) and cultured mesenchymal core cells.

References

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Citations

Jan 6, 1996·BMJ : British Medical Journal·C H GravholtJ Hansen
Mar 1, 2002·Human Reproduction·Manuel Rodríguez-GonzálezJosé Remohí
Jan 1, 2014·Journal of Clinical Medicine·Giovanni MonniMaria Angelica Zoppi
Jun 1, 1997·American Journal of Obstetrics and Gynecology·J D Goldberg, M M Wohlferd
Mar 1, 1996·American Journal of Obstetrics and Gynecology·O P PhillipsL P Shulman
Jan 8, 1999·American Journal of Medical Genetics·W T HsuR R Schreck
May 1, 1996·Prenatal Diagnosis·M J GriffithsH M Stibbe
May 14, 1998·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·K Benirschke
Apr 1, 1994·Prenatal Diagnosis·A GarberJ M Graham
Dec 1, 1995·Prenatal Diagnosis·S ArtanI Dölen
Dec 1, 1992·Prenatal Diagnosis·J G Post, J G Nijhuis
Nov 1, 1992·Prenatal Diagnosis·A D DorfmannJ D Schulman
May 1, 1992·Prenatal Diagnosis·D H LedbetterK L Copeland
Mar 1, 1994·American Journal of Medical Genetics·T C Falik-BorensteinR R Schreck
Aug 15, 1993·American Journal of Medical Genetics·A S DeviP Benn
Nov 15, 1992·American Journal of Medical Genetics·P G KratzerR N Taylor
Mar 25, 2006·Prenatal Diagnosis·Katherine NeiswangerUrvashi Surti
Oct 29, 2005·Human Reproduction·Charles E Boklage
Aug 22, 2006·British Journal of Hospital Medicine·Anja PinborgAnders Nyboe Andersen

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