PMID: 16502988Mar 1, 2006Paper

Resorption and tolerance of the high doses of ferrous sulfate and ferrous gluconate in the patients on peritoneal dialysis

Vojnosanitetski pregled. Military-medical and pharmaceutical review
Mirjana LausevićBiljana Stojimirović

Abstract

Iron supplementation plays a crucial role in peritoneal dialysis (PD) patients. Oral iron substitution is more convenient than intravenous therapy in PD patients, but impaired absorption and adverse effects may be limiting factors for oral treatment. The aim of this study was to compare the absorption and side effects of high doses ferrous sulphate and ferrous gluconate in PD patients. Blood samples were taken from 29 PD patients at baseline, as well as 2, 4 and 8 hours after oral intake of 4 ferrous sulphate tablets (containing 105 mg elemental iron per tablet). The test was repeated using 8 ferrous gluconate drinkable ampoules (containing 50 mg elemental iron per ampoule). The maximal increase in serum iron level during the test with iron sulphate was 113.51 +/- 103.37% versus the initial values of 183.87 +/- 37.38% during the ferrous gluconate test. The maximal values of serum iron after the intake of ferrous sulphate were 26.23 +/- 9.95 micromol/l versus 30.97 +/- 8.65 micromol/l after the intake of ferrous gluconate. There was a statistically significant difference between these two groups. Six patients showed an increase in serum iron of more than 300% after a high ferrous gluconate dose, while in 15 of the patients serum...Continue Reading

References

Mar 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S Fishbane, J K Maesaka
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M P Kooistra, J J Marx
Mar 20, 1999·Kidney International. Supplement·A Vychytil, M Haag-Weber
Feb 24, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D RichardsonE J Will
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard A ZagerHaimanot Wasse
Aug 19, 2006·Srpski arhiv za celokupno lekarstvo·Mirjana LausevićBiljana Stojimirović
Feb 9, 2008·Medicinski pregled·Natasa JovanovićBiljana Stojimirović

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