PMID: 9159153May 27, 1997Paper

Resource competition as a mechanism for B cell homeostasis

Proceedings of the National Academy of Sciences of the United States of America
A R McLeanA A Freitas

Abstract

Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.

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Citations

Oct 1, 1998·European Journal of Immunology·M M Rosado, A A Freitas
Dec 11, 2003·American Journal of Physical Anthropology·Thomas W McDade
May 31, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Laura S TremlMichael P Cancro
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Sep 25, 2009·Proceedings. Biological Sciences·Helen R FryerAngela R McLean
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Feb 14, 2004·Immunological Reviews·Michael P Cancro
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Jul 6, 2019·Frontiers in Cell and Developmental Biology·Geoffrey Brown, Rhodri Ceredig
Jun 20, 1997·Science·R B Gallagher

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