Resources used in the treatment of perianal Crohn's disease and the results in a real-life cohort

Gastroenterología y hepatología
Cristina Rubín de Célix VargasF Bermejo

Abstract

To study the multidisciplinary management of patients with Crohn's disease (CD) and perianal disease (perianal Crohn's disease, PCD), as well as to analyse a possible relationship between the recurrence of perianal symptoms, the type of fistula and the treatment used. Descriptive, retrospective study of patients with PCD who were treated in the Inflammatory Bowel Disease Unit. Epidemiological, clinical, diagnostic and therapeutic variables were collected, as well as clinical outcome and response to treatment. Of the 300 patients who attended the outpatient clinic at a university hospital, 65 had PCD. Sixteen simple fistulas (24.6%) and 49 complex fistulas (75.4%) were diagnosed. The most commonly used diagnostic technique was the endoanal ultrasound (45%). Antibiotics were used in 77.4% of patients, and 70% needed anti-TNF therapy to manage the PCD. Surgery was performed on 75.4% of the patients overall. PCD recurred in 41.5% of cases, requiring a change of the biological drugs administered and/or surgery. Complex fistulas were more likely to require surgery (P=.012) and recurrence of PCD was also more common with complex fistulas (P=.036). Management of PCD must be multidisciplinary and combined. Most patients with complex PCD...Continue Reading

References

Jul 15, 1995·Annals of Internal Medicine·D C PearsonL R Sutherland
May 6, 1999·The New England Journal of Medicine·D H PresentS J van Deventer
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
Nov 5, 2003·Gastroenterology·William J SandbornUNKNOWN American Gastroenterological Association Clinical Practice Committee
Oct 12, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bruce E SandsUNKNOWN ACCENT II Study
Oct 17, 2006·Diseases of the Colon and Rectum·Syed A HyderBruce D George
Apr 9, 2009·The American Journal of Gastroenterology·Jean-Frédéric ColombelParvez M Mulani
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 17, 2011·The American Journal of Gastroenterology·Khurram J KhanPaul Moayyedi
Apr 20, 2012·Diseases of the Colon and Rectum·Muhammed R S SiddiquiRobin K Phillips
Aug 24, 2013·The New England Journal of Medicine·William J SandbornUNKNOWN GEMINI 2 Study Group
Feb 28, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E Joline de GroofChristianne J Buskens
Dec 14, 2016·The New England Journal of Medicine·Brian G FeaganUNKNOWN UNITI–IM-UNITI Study Group
Aug 10, 2017·Nature Reviews. Gastroenterology & Hepatology·Julián Panés, Jordi Rimola

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