Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia

Journal of Neurology, Neurosurgery, and Psychiatry
D RanouxM Zuber

Abstract

Botulinum toxin type A is a potent neuromuscular paralyzing agent used in various disorders including cervical dystonia. Two preparations of botulinum toxin are now commercially available ( Dysport and Botox), but much controversy remains about their respective potencies. The aim of the study was to compare the efficacy of Botox with two different ratios of Dysport. A double blind, randomised, three period cross over study involving 54 patients with cervical dystonia was performed. The patients received the following treatments in a randomised order: Botox at the usually effective dose, Dysport at a dose of 1:3 (conversion factor of 3 between Botox and Dysport units-that is, one Botox unit=three Dysport units) and at a dose of 1:4 (conversion factor of four). The improvement of the Tsui (primary outcome criteria) and of the TWSTRS pain scales between baseline and a control visit 1 month after each of the three injections, as well as the incidence of adverse events, were assessed. Comparison of the Tsui scores and of the TWSTRS pain scores showed a better effect on impairment and pain with Dysport 1:3 (p=0.02 and 0.04, respectively) and 1:4 (p=0.01 and 0.02, respectively) than with Botox. The number of adverse events was higher ...Continue Reading

Citations

Nov 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ammar Nassri, Zeeshan Ramzan
Aug 29, 2019·Toxins·Steven Bellows, Joseph Jankovic
May 31, 2019·ACS Sensors·Hui-Pin Cheng, Han-Sheng Chuang

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