Respective roles of acquired and congenital infections in presumed ocular toxoplasmosis

American Journal of Ophthalmology
Emmanuelle DelairAntoine Brézin

Abstract

To analyze the roles of acquired or congenital infections in cases of ocular toxoplasmosis, and to compare their clinical manifestations. Retrospective, observational case series. We analyzed the charts of consecutive patients with a diagnosis of ocular toxoplasmosis. Data from the French program for the prevention of congenital toxoplasmosis were used to assess the origin of infection. The data included patients' serologic status prior to their ocular manifestations and patients' mothers' serologic status before, during, and/or after pregnancy. Infections were categorized as congenital, acquired, or unknown. Of 425 cases of ocular toxoplasmosis, 100 (23.5%) were acquired, 62 (14.6%) were congenital, and 263 (61.9%) were of unknown origin. At the time of the study, the mean age of the patients with congenital ocular toxoplasmosis was 9.1 +/- 8.8 years, and was 21.7 +/- 12.6 years in the patients with acquired ocular toxoplasmosis (P < .0001). Bilateral chorioretinitis was observed in 4% of acquired cases and in 43.5% of congenital cases (P < .0001). In acquired infections, mean decimal visual acuity (VA) was 1.0 (logarithm of the minimum angle of resolution [logMAR] 0.0 +/- 1 line) in the best eye and 0.4 (logMAR 0.4 +/- 5 line...Continue Reading

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Citations

Oct 2, 2012·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Soumyava BasuB Manohar Babu
Oct 15, 2013·The Journal of Infection·Florence Robert-Gangneux
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Mar 25, 2011·Ocular Immunology and Inflammation·Emmanuelle DelairAntoine Brézin
Jul 28, 2020·Progress in Retinal and Eye Research·Justine R SmithJoão M Furtado

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