PMID: 6401320Jan 1, 1983Paper

Respective roles of ammonia, amino acids, and medium-sized molecules in the pathogenesis of experimentally induced acute hepatic encephalopathy

Journal of Neurochemistry
J DenisP Opolon

Abstract

Ammonia, amino acids (AA), and middle molecules (MM) have been implicated in the pathogenesis of experimentally induced acute hepatic coma in the pig. Hemodialysis (HD) using either a low- (Cuprophan = CU) or a high-permeability (polyacrylonitrile = AN 69) membrane has demonstrated the role of MM. Selective hemodialysis (SHD) of AA or NH3 and MM was performed by adding either NH3 (group I) or AA (group II) to the dialysate during AN 69 HD; for MM, SHD only was performed by adding NH3 and AA to the dialysate (group III). In group I the brain levels of tyrosine were similar to those in undialyzed animals with decreased striatal dopamine and decreased norepinephrine in the midbrain only. Brain tryptophan was higher than normal, but brain levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid (5-HT, 5-HIAA) were within normal limits. In group II, despite an efficient NH3 clearance, brain NH3 levels were as high as in group I and did not correlate with plasma levels. Brain tyrosine (despite tyrosine overload of the dialysate) was lower than in group I; striatal dopamine decreased (but to a lesser extent than in group I), and norepinephrine was normal. Brain tryptophan was higher than normal, with an increase in brain 5-HT and ...Continue Reading

References

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Citations

Mar 1, 1986·Metabolic Brain Disease·A M Mans, R A Hawkins
Feb 1, 1987·Neurochemical Pathology·R A HawkinsJ F Biebuyck
Jan 1, 1985·Neurochemistry International·F ChaouloffJ L Elghozi
Jul 5, 2003·The Journal of Surgical Research·Masaya ShitoMehmet Toner
May 25, 2010·BMC Emergency Medicine·Shinju ArataKazuo Aoyagi
May 1, 1995·In Vitro Cellular & Developmental Biology. Animal·A LazarW S Hu
Nov 1, 1992·Journal of Veterinary Internal Medicine·J E Maddison
Dec 18, 2012·Journal of Neuropathology and Experimental Neurology·Adeline VanderverRaphael Schiffmann
Nov 1, 1993·American Journal of Surgery·S L NybergF B Cerra
Feb 1, 1983·European Journal of Clinical Investigation·P Opolon
Mar 20, 2013·Cell Transplantation·Hongling LiuScott L Nyberg
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P GripponP Opolon

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