PMID: 2497240Feb 1, 1989Paper

Respirable form of crystals of cromoglycic acid

Journal of Pharmaceutical Sciences
H K Chan, I Gonda

Abstract

Respirable crystals of cromoglycic acid (CA) were prepared by precipitation of CA with hydrochloric acid from aqueous solutions of cromolyn sodium and subsequent recrystallization from hot water or mixtures of dimethyl sulphoxide and water. The properties of the materials were established by melting point measurements, UV, IR, and NMR spectroscopy, and X-ray diffraction. Aerosols of CA were generated by nebulization of dilute CA suspensions and drying. The aerodynamic size distribution of CA in the dried aerosols was found by cascade impaction, and could be characterized by a logarithmic normal function with a mass median aerodynamic diameter (MMAD) of 0.7 micron and geometric standard deviation (sigma g) of 1.9. The likely advantages and problems of CA aerosols in the prevention of asthma are discussed.

References

Mar 14, 1959·Nature·K R MAY

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Citations

Aug 21, 2008·Expert Opinion on Drug Delivery·Hak-Kim Chan
Sep 27, 2007·Journal of Pharmaceutical Sciences·Handoko AdiPaul M Young
Apr 5, 2011·Advanced Drug Delivery Reviews·Hak-Kim Chan, Philip Chi Lip Kwok
Feb 18, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yoen-Ju Son, Jason T McConville
Oct 14, 2008·International Journal of Pharmaceutics·P TangJ A Raper
Aug 14, 2012·The Journal of Pharmacy and Pharmacology·Yoen-Ju Son, Jason T McConville
Oct 19, 2004·International Journal of Pharmaceutics·Abdolhossien Rouholamini NajafabadiMorteza Rafiee-Tehrani
Jun 1, 1995·Journal of Pharmaceutical Sciences·H K Chan, I Gonda

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