Respiration in the filarial nematode Brugia pahangi

International Journal for Parasitology
T A PagetD Lloyd

Abstract

Glucose-supported O2 uptake in the filarial nematode Brugia pahangi was partially inhibited by antimycin A (30-40%), with the remaining activity being sensitive to o-hydroxydiphenyl or salicylhydroxamic acid (SHAM). The production of CO2 by B. pahangi in the presence of D-glucose was stimulated by O2; the stimulation of CO2; the stimulation of CO2 production was sensitive to antimycin A. The O2 dependencies of respiration showed that the apparent O2 affinity for B. pahangi was diminished in the presence of antimycin A; O2 thresholds for inhibition of respiration were observed which showed that the alternative electron transport pathway was less sensitive to inhibition at elevated O2 concentrations. H2O2 production and its excretion could be detected in whole B. pahangi; higher rates were observed in the presence of the uncoupler carbonyl cyanide m-chlorophenylhydrazone. The effects of inhibitors on H2O2 production suggest two sites of H2O2 production, one associated with the classical antimycin A-sensitive pathway, the other with the alternative respiratory pathway. The similarity in the O2 dependencies of H2O2 production and respiration may indicate that H2O2 production is involved in O2-mediated toxicity. Succinate and malate...Continue Reading

References

Jan 15, 1987·Molecular and Biochemical Parasitology·T A PagetD Lloyd
Oct 1, 1986·International Journal for Parasitology·J BarrettP E Butterworth
Mar 1, 1985·Molecular and Biochemical Parasitology·A H Mendis, S Townson
Jan 1, 1980·Methods of Biochemical Analysis·H DegnA Ormicki
Nov 1, 1980·The Biochemical Journal·J F Turrens, A Boveris
Jul 15, 1983·The Biochemical Journal·D LloydJ L Williams
Apr 1, 1983·Archives of Biochemistry and Biophysics·J Blum, I Fridovich
Mar 1, 1981·Archives of Biochemistry and Biophysics·J N Siedow, D M Bickett
Apr 1, 2000·Journal of the American Aging Association·J J Thaden, R J Shmookler Reis

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Citations

Jun 1, 1992·Molecular and Biochemical Parasitology·A H MendisW B Grubb
Mar 1, 1996·Journal of Helminthology·M S Omar, A M Raoof
Aug 1, 1990·Experimental Parasitology·T A PagetD Lloyd

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