Respiration of chemodenervated goats in acute metabolic acidosis

Respiration Physiology
R A SteinbrookV Fencl

Abstract

In awake goats before and after ablation of carotid bodies (CBx) we studied the effect of acute metabolic acidosis (AMA) produced by intravenous infusion of HCl on composition of arterial blood and CSF, and on ventilatory responsiveness to hyperoxic CO2 rebreathing AMA caused decrease in PaCO2 (breathing air at rest) indicating that alveolar ventilation was increased relative to CO2 production; position of CO2 response curves was shifted toward lower values of PCO2. These changes were similar before and after CBx, though the levels of PCO2 in arterial blood during air breathing at rest, and in expired gas at a given level of ventilation during CO2 rebreathing, were higher after CBx. We conclude that a respiratory adaptation to AMA does occur in goats deprived of peripheral chemoreceptors, and is probably mediated by the central chemoreceptors.

References

Jan 1, 1975·Respiration Physiology·M J Miller, S M Tenney
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Citations

Jan 1, 1987·Respiration Physiology·J J SchuitmakerC N Olievier
Sep 1, 1994·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J A Dempsey, C A Smith
Sep 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·H V Forster, L G Pan
Nov 8, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Genfa WangJingcheng Dong

Related Concepts

Metabolic Acidosis
Acute Disease
Metazoa
Arteries
Blood Chemical Analysis
Carbon Dioxide
Carotid Body
Cerebrospinal Fluid
Denervation
Goat

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