Respiration under control of uncoupling proteins: Clinical perspective

Hormone Research
Tobias Nübel, Daniel Ricquier

Abstract

The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is uniquely present in mitochondria of brown adipocytes, thermogenic cells that regulate body temperature in small rodents, hibernators and mammalian newborns. In these cells, UCP1 acts as a proton carrier activated by free fatty acids and creates a shunt between complexes of the respiratory chain and ATP-synthase resulting in a futile proton cycling and dissipation of oxidation energy as heat. Recent identification of new homologues to UCP1 expressed in brown and white adipose tissue, muscle, brain and other tissues together with the hypothesis that these novel uncoupling proteins (UCPs) may regulate thermogenesis and/or fatty acid metabolism and furthermore may protect against free radical oxygen species production have generated considerable optimism for rapid advances in the identification of new targets for pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases. However, since the physiological and biochemical roles of the novel UCPs are not yet clear, the main challenge today consists first of all in providing mechanistic explanation for their function...Continue Reading

References

Apr 16, 1998·Biochimica Et Biophysica Acta·V P Skulachev
Aug 7, 1998·Biochimica Et Biophysica Acta·P JezekK D Garlid
Dec 5, 1998·The International Journal of Biochemistry & Cell Biology·P Jezek, K D Garlid
Dec 16, 1998·FEBS Letters·M V CarreteroM A Avila
Dec 22, 1999·Biochemical and Biophysical Research Communications·Y KagawaH Endo
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·R Barazzoni, K S Nair
Mar 10, 2001·Biochimica Et Biophysica Acta·R K Porter
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·J KernerC L Hoppel
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·F SavagnerY Malthiery
May 16, 2002·The Journal of Biological Chemistry·Edward M MillsToren Finkel
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos Bernal-MizrachiClay F Semenkovich
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mary-Ellen HarperM Karen Newell
Jan 15, 2003·Experimental Physiology·Martin Klingenspor
Jan 29, 2003·Circulation·J BlancZ Mallat
May 6, 2003·Biochemical and Biophysical Research Communications·Mark P Mattson, Dong Liu
May 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana M RodríguezAndreu Palou
May 21, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stefan-Martin HerrmannEva Brand
Aug 13, 2003·The EMBO Journal·Karim S EchtayMartin D Brand
Aug 28, 2003·The Journal of Biological Chemistry·Sophie RoussetAnne-Marie Cassard-Doulcier
Nov 5, 2003·Pflügers Archiv : European journal of physiology·Ferdinando Palmieri
Dec 4, 2003·Biochemical Society Transactions·H NohlK Staniek
Jan 30, 2004·Diabetes·Sophie RoussetDaniel Ricquier
Jan 30, 2004·Diabetes·Catherine B ChanMichael B Wheeler
Feb 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A M Rodríguez, A Palou
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jacob B HansenKarsten Kristiansen
Aug 6, 2004·The Proceedings of the Nutrition Society·Patrick Schrauwen, Matthijs K C Hesselink

❮ Previous
Next ❯

Citations

Jul 6, 2010·Biogerontology·Giuseppe PassarinoDina Bellizzi
Feb 26, 2013·PLoS Neglected Tropical Diseases·Javier CarriónM Mar González-Barroso
Jun 4, 2008·Journal of the American Veterinary Medical Association·Philip RoudebushSean J Delaney
Aug 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tim J L Van De ParreGuido R Y De Meyer
Sep 17, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva Valouskova, Martin Modriansky
Mar 17, 2010·FEBS Letters·Yalin Emre, Tobias Nübel
Dec 17, 2009·Mitochondrion·Gyorgy Baffy
Jul 22, 2008·American Journal of Surgery·Melanie G CreeRobert R Wolfe
Aug 25, 2009·The American Journal of Pathology·Aurélia De PauwThierry Arnould
Aug 13, 2015·Journal of Thermal Biology·I Kralova LesnaS Vybiral
Apr 7, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lara MilaneMansoor Amiji
May 19, 2009·Journal of Hepatology·György Baffy
Dec 7, 2007·Biochimica Et Biophysica Acta·Tobias NübelFrédéric Bouillaud
Feb 23, 2011·Chemistry & Biology·Eduardo RialAlma Viso
Apr 30, 2017·The Journal of Endocrinology·Karla J SuchackiWilliam P Cawthorn
Aug 1, 2008·Expert Review of Respiratory Medicine·Nikolaj Ture GregersenAngelo Tremblay
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Jennifer HonekYihai Cao
Jun 28, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Lara MilaneMansoor Amiji

❮ Previous
Next ❯

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.