PMID: 9538357Apr 16, 1998Paper

Respiratory allergy in laboratory animal workers: a retrospective cohort study using pre-employment screening data

Occupational and Environmental Medicine
H KruizeE van der Beek

Abstract

To study the role of exposure, atopy, and smoking in the development of laboratory animal allergy (LAA) in a retrospective cohort study. Between 1977 and 1993, 225 people received a pre-employment screening when they started a job at a Dutch research institute where they were going to work with laboratory animals. After active follow up 136 of them (60.4%) could be traced and were sent a questionnaire with extensive questions on allergic symptoms, smoking habits, and job history. 122 people (89.7%) sent back a completed questionnaire. Those who were accepted for a job at the institute and did not have allergic symptoms at the start of the job were selected as cohort members. After selecting people with complete data on start and end date of jobs, exposure intensity, atopy, and smoking, the cohort consisted of 99 people with an average time of follow up of 9.7 years. LAA was defined as a positive response to a set of questions in the questionnaire. The mean number of hours a week a person was exposed to laboratory animals at entry of the cohort was used as a surrogate for exposure, and was divided into four categories. 19 cohort members (19.2%) reported LAA. More people with asthmatic symptoms were found in the high exposure cat...Continue Reading

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Citations

Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Susan M Tarlo, Gary M Liss
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tamara T PerryPeyton A Eggleston
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Feb 5, 2000·Occupational and Environmental Medicine·D HeederikM J Nieuwenhuijsen
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Mar 4, 2014·Industrial Health·Basilua Andre MuzemboNarufumi Suganuma
May 1, 2005·Expert Review of Clinical Immunology·Paul Cullinan
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SiracusaA Marabini
Jul 23, 2003·American Journal of Industrial Medicine·Päivikki SusitaivalMarc B Schenker
Dec 19, 2012·Lab Animal·Massimo CorradiAntonio Mutti
Dec 26, 2002·Journal of Occupational and Environmental Medicine·Leslie E Goodno, Gregg M Stave
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Oct 29, 2002·Journal of Environmental Monitoring : JEM·Anne Renström

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