Respiratory allergy to trimellitic anhydride in rats: concentration-response relationships during elicitation

Inhalation Toxicology
J H ArtsC F Kuper

Abstract

The present study investigated whether airway responses of sensitized rats to trimellitic anhydride (TMA) were concentration dependent and whether these were related to irritation by TMA. Groups of BN and Wistar rats were sensitized by two dermal applications of TMA (50% w/v, followed by 25% w/v in vehicle). Controls received vehicle (acetone-olive oil 4:1, v/v). All animals were challenged 3 wk after the first sensitization by inhalation of one of a range of concentrations of TMA (0.2-61 mg/m3 for BN rats, 15-250 mg/m3 for Wistar rats). Breathing pattern, breathing frequency, and tidal volume were measured before, during, and after challenge to assess allergic and irritative airway responses. One day after challenge, nonspecific airway responsiveness to a range of concentrations of methacholine was measured. At necropsy on the same day, blood was withdrawn for measuring total serum immunoglobulin E (IgE) and organs were weighed. Larynx, trachea and lungs were examined histopathologically. In BN rats, TMA sensitization elevated total IgE levels; subsequent inhalation challenge with 2 mg/m3 of TMA and higher caused laryngeal inflammation with squamous epithelial metaplasia, and pulmonary hemorrhages. Concentration-related decrea...Continue Reading

References

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Citations

Sep 26, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Josje H E ArtsC Frieke Kuper
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Sep 7, 2011·Toxicology·C Frieke KuperJosje H E Arts
Nov 21, 2007·Toxicology and Applied Pharmacology·Darrell R BoverhofMichael R Woolhiser
May 17, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Rob VandebrielHenk van Loveren
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
May 15, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Berislav BosnjakBoska Hrvacić
Jun 15, 2007·Alternatives to Laboratory Animals : ATLA·Ian KimberUNKNOWN European Centre for the Validation of Alternative Methods
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Dec 22, 2017·NPJ Vaccines·Danuta Gutowska-Owsiak, Graham S Ogg

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