PMID: 3769402Nov 1, 1986Paper

Respiratory and cardiovascular effects of central and peripheral intravenous injections of capsaicin in man: evidence for pulmonary chemosensitivity

Clinical Science
A J WinningA Guz

Abstract

The respiratory and cardiovascular effects of capsaicin injection into the superior vena cava and an arm vein were studied in three normal subjects. No changes were seen in tidal volume, inspiratory time or expiratory time after capsaicin injection. Instantaneous heart rate, systolic blood pressure and diastolic blood pressure remained unchanged. Central and peripheral intravenous injections of capsaicin but not control solution above a threshold of 0.5 micrograms/kg produced dose-dependent sensations sequentially in the chest, face, rectum and extremities. The chest sensation, a 'raw, burning' feeling, occurred 3-4 s after central capsaicin injection. No subject reported feeling breathless. In one subject the maximum tolerable dose of capsaicin (4 micrograms/kg) produced paroxysmal coughing 3.9 s after a central injection. In two of the subjects capsaicin injection was repeated after inhalation of a 5% bupivacaine aerosol (aerodynamic mass median diameter 4.8 micron), sufficient to block the cough reflex to a 5% citric acid aerosol. Prior inhalation of local anaesthetic aerosol abolished the chest sensation after capsaicin injection; the other sensations were unaffected. This study demonstrates that stimulation of receptors ac...Continue Reading

Citations

Nov 6, 2010·Chest·Nausherwan K Burki, Lu-Yuan Lee
Feb 23, 2010·Otolaryngologic Clinics of North America·Brendan J Canning
Mar 2, 2010·Pulmonary Pharmacology & Therapeutics·Nausherwan K Burki, Lu-Yuan Lee
Jan 15, 2009·Pulmonary Pharmacology & Therapeutics·John J Adcock
Jul 1, 2008·Respiratory Physiology & Neurobiology·Lu-Yuan Lee
Jul 9, 2002·Pulmonary Pharmacology & Therapeutics·Lu-Yuan LeeQihai Gu
Dec 2, 2006·Respiratory Research·Nausherwan K BurkiLu-Yuan Lee
Mar 10, 2007·Biochimica Et Biophysica Acta·Yanlin Jia, Lu-Yuan Lee
Mar 8, 2011·British Journal of Anaesthesia·T Nishino
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Dec 1, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yang-Ling ChouBrendan J Canning
Sep 21, 2004·Journal of Applied Physiology·Nausherwan K BurkiLu-Yuan Lee
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C J FowlerC G Fowler
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Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem
Jan 5, 2021·Frontiers in Physiology·Michael J M FischerArpad Szallasi
Jul 22, 2019·Pulmonary Pharmacology & Therapeutics·Emma WallacePhoebe Macrae
Jul 27, 2021·Experimental and Therapeutic Medicine·Mihai-Daniel DumitracheConstantin Caruntu

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