Respiratory and circulatory effects of parietal pleural afferent stimulation in rabbits

Journal of Applied Physiology
Yves Jammes, Stéphane Delpierre

Abstract

Respiratory symptoms accompanying pleural diseases combine dyspnea, tachypnea, rapid shallow breathing, and sometimes hypotension. There are no experimental data on the changes in respiratory and circulatory functions elicited by the activation of pleural afferents. After removal of all muscles covering the 5th to 10th intercostal spaces, we investigated in paralyzed, vagotomized rabbits the changes in phrenic discharge, transpulmonary pressure, and systemic arterial pressure in response to an outwardly directed force exerted on the parietal pleura or the local application of solutions containing lactic acid or inflammatory mediators. Mechanical stimulation of the pleura induced an immediate decrease in both integrated phrenic discharge and arterial blood pressure, the responses being positively correlated with the magnitude of force applied on the pleura. No accompanying changes in ventilatory timing, transpulmonary pressure, or heart rate were measured. Lactic acid solution also elicited an inhibition of phrenic activity and a fall in blood pressure. Section of the internal intercostal nerves supplying the stimulated intercostal spaces totally abolished the responses to mechanical stimulation or lactic acid. An inflammatory m...Continue Reading

References

Feb 1, 1975·Archives internationales de physiologie et de biochimie·Y JammesC Grimaud
Aug 1, 1976·Respiration Physiology·A J Winning, J G Widdicombe
Mar 1, 1986·Journal of Applied Physiology·Y JammesC Roussos
Oct 1, 1970·Respiration Physiology·J E Remmers
Aug 1, 1971·The American Journal of Physiology·F L Eldridge
Jun 1, 1969·The Journal of Physiology·R B Godwin-Austen
May 1, 1983·The American Journal of Medicine·M EstenneA De Troyer
Feb 1, 1983·Respiration Physiology·J P Albano, L Garnier
Feb 1, 1982·Respiration Physiology·D F Speck, C L Webber
Jan 1, 1980·Respiration; International Review of Thoracic Diseases·I Brook
Mar 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M P KaufmanD G Baker
May 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R Shannon
Jul 1, 1995·Journal of Applied Physiology·A De Troyer, A Legrand
Nov 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J W HottV B Antony
Dec 5, 1997·The European Respiratory Journal·C Kroegel, V B Antony
Jan 1, 1997·Somatosensory & Motor Research·C Wedekind
Aug 12, 1999·Anesthesiology·R R SharmaS Reiz
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·D LeducA De Troyer
May 15, 2002·Clinical Physiology and Functional Imaging·Stéphane V BerdahYves Jammes
Apr 1, 1961·Physiological Reviews·J MEAD
Jun 25, 2005·The Journal of Physiology·Yves JammesStéphane Delpierre

❮ Previous
Next ❯

Citations

Dec 25, 2013·Journal of Forensic and Legal Medicine·Gabriele RoccaFrancesco Ventura
Dec 16, 2006·American Journal of Respiratory Cell and Molecular Biology·Isabel PintelonDirk Adriaensen
Jul 1, 2008·Seminars in Arthritis and Rheumatism·Sophie P Toya, George E Tzelepis
Nov 17, 2010·Molecular and Cellular Endocrinology·V K KouritasC Hatzoglou
Oct 28, 2008·Respiratory Physiology & Neurobiology·John Widdicombe
Feb 5, 2013·The Journal of Rheumatology·Lauren A HendersonPeter A Nigrovic
Jul 12, 2019·BMC Pulmonary Medicine·Yun-Yan WanDian-Jie Lin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.