Respiratory and hematological adaptations of young and older Aymara men native to 3600M

American Journal of Human Biology : the Official Journal of the Human Biology Council
C M BeallE Vargas

Abstract

This paper reports the results of a study designed to test the hypothesis that an inevitable concomitant of aging at high altitudes is chronic mountain sickness resulting from excess erythrocytosis secondary to exaggerated hypoxemia caused by aging processes in the respiratory system. It compares age differences in respiratory system function in oxygenating the blood measured as percent O2 saturation of arterial hemoglobin during wakefulness and sleep and in erythrocytosis measured as hemoglobin concentration in 17 young (22-35 years) and 16 older (47-68 years) rural and urban resident Bolivian Aymara men, healthy lifelong residents of 3,500-4,000 m who were tested at 3,600 m. The results do not support the hypothesis. Older urban men are significantly more hypoxemic during wakefulness and sleep than young urban men, while there are no age differences in the degree of hypoxemia among the rural residents. However, older urban men do not have the higher hemoglobin concentration predicted by the hypothesis. Both urban and rural older men have lower hemoglobin concentration than their young counterparts, a finding not attributable to age differences in nutritional status or testosterone concentration. Despite their relatively low h...Continue Reading

References

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Citations

Feb 7, 1998·American Journal of Physical Anthropology·C M BeallC Gonzales
Jan 21, 2000·American Journal of Physical Anthropology·E Tarazona-SantosD Pettener
Jan 23, 1999·American Journal of Physical Anthropology·C M BeallC Gonzales
Jul 28, 2016·High Altitude Medicine & Biology·Katherine HealyWilliam Checkley

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