Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis

The Journal of Pediatrics
Kim M HareAnne B Chang

Abstract

To test the hypothesis that bacterial density, strain diversity, and concordance of pathogens between upper and lower airways are higher in children with bronchiectasis than in those with non-bronchiectatic conditions. Nasopharyngeal (NP) swabs and bronchoalveolar lavage (BAL) fluid were cultured from 45 Indigenous children with bronchiectasis and 30 non-Indigenous children with non-bronchiectatic respiratory symptoms. Lower airway infection was defined as >10(4) colony-forming units of respiratory bacteria/mL of BAL fluid. Concordance was determined by phenotype or genotype. NP carriage of Streptococcus pneumoniae, nontypable Haemophilus influenzae (NTHi), and Moraxella catarrhalis, and lower airway infection by NTHi (47% vs 3%), were detected significantly more often in the children with bronchiectasis than in those without this condition. BAL specimens from the infected Indigenous children also showed greater strain diversity (71% vs 0%). Strain concordance in NP and BAL cultures was high in both infected subgroups. The high density and diversity of respiratory bacteria, along with strain concordance between upper and lower airways, found in Indigenous children with bronchiectasis suggest a possible pathogenic role of recurr...Continue Reading

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Citations

Feb 2, 2013·Current Infectious Disease Reports·Jim BartleyCarlos A Camargo
Oct 29, 2005·American Journal of Respiratory and Critical Care Medicine·Rosemary J BoytonDaniel M Altmann
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Michael M TunneyJ Stuart Elborn
Apr 25, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Asha C BowenJonathan R Carapetis
Feb 14, 2014·Archives of Disease in Childhood·Vikas GoyalAnne B Chang
Dec 7, 2013·Expert Review of Respiratory Medicine·Kerry-Ann F O'GradyKeith Grimwood
Jul 20, 2012·Expert Opinion on Emerging Drugs·Anne B ChangLucas R Hoffman
Mar 5, 2015·Expert Opinion on Emerging Drugs·Anne B ChangLucas R Hoffman
Dec 5, 2015·Pediatric Pulmonology·Anne B ChangKeith Grimwood
Feb 4, 2016·Pediatric Pulmonology·Vikas GoyalAnne B Chang
Jun 29, 2011·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Keisuke SunakawaSatoshi Iwata
Apr 5, 2011·Paediatric Respiratory Reviews·Keith Grimwood
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Apr 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Danielle F WurzelAnne B Chang
May 12, 2012·The Journal of Pediatrics·Anne B ChangJohn W Upham
Mar 17, 2016·Annual Review of Pathology·Rosemary J Boyton, Daniel M Altmann
Jul 28, 2016·Pediatric Pulmonology·Kerry-Ann F O'GradyAnne B Chang
May 26, 2017·Expert Review of Respiratory Medicine·Danielle F Wurzel, Anne B Chang
Sep 19, 2017·Pediatric Pulmonology·Kim M HareKeith Grimwood
Jul 10, 2018·Pediatric Pulmonology·Mikhail KazachkovLeopoldo N Segal
Nov 29, 2013·Clinical and Vaccine Immunology : CVI·Heidi C Smith-VaughanErin P Price

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