PMID: 8591699Aug 1, 1995Paper

Respiratory burst activity of monocytes from patients with non-insulin-dependent diabetes mellitus

Diabetes Research and Clinical Practice
F Y Chang, M F Shaio

Abstract

Monocytes from patients with poorly controlled non-insulin-dependent diabetes mellitus (NIDDM) show a decrease in intracellular bactericidal function. To determine whether this reduced bactericidal function is mediated by an impaired oxygen-dependent mechanism, we assayed the production of superoxide (O2-) and hydrogen peroxide (H2O2) by monocytes from poorly controlled NIDDM patients (n = 12), well controlled NIDDM patients (n = 12) and healthy subjects (n = 16). Using phorbol myristate acetate (PMA) as stimulant, the production of O2- by fresh monocytes was significantly decreased in poorly controlled NIDDM patients (231 +/- 30 nmol/mg protein/2-h) as compared with that of well controlled NIDDM patients (430 +/- 81 nmol/mg protein/2-h) and that of healthy subjects (399 +/- 61 nmol/mg protein/2-h), respectively (P < 0.05). Using opsonized zymosan (OZ) as stimulant, the production of O2- by fresh monocytes was also notably decreased in patients with poorly controlled NIDDM (312 +/- 42 nmol/mg protein/2-h) as compared with that of patients with well controlled NIDDM (688 +/- 92 nmol/mg protein/2-h) and that of healthy subjects (539 +/- 96 nmol/mg protein/2-h), respectively (P < 0.05). Poorly controlled NIDDM patients had a signi...Continue Reading

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Citations

Jan 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hideaki YamasawaYukihiko Sugiyama
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jennifer M DiPentaRené J L Murphy
Nov 11, 2006·Journal of Leukocyte Biology·Yong DingThomas E Van Dyke
Jun 10, 2011·Immunobiology·Yuji TakedaIchiro Wakabayashi
May 23, 2014·Diabetes/metabolism Research and Reviews·Hang HuChunmao Han
Jul 21, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Melpomeni PeppaSotirios A Raptis
May 27, 2015·The Journal of Infectious Diseases·Helen McIlleronAndrew Owen
Dec 7, 2018·Annals of Surgical Treatment and Research·Hyung Min HahnIl Jae Lee
Sep 9, 2017·BMC Infectious Diseases·María Teresa HerreraMartha Torres
Jul 3, 2020·Diabetes & Metabolism Journal·Junghyun NohKun Ho Yoon
May 28, 2021·Diabetes/metabolism Research and Reviews·Yongze ZhangSunjie Yan

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