Respiratory complications and their management in motor neuron disease

Brain : a Journal of Neurology
R S HowardL Loh

Abstract

Although respiratory insufficiency is common in the advanced stages of motor neuron disease, some patients may develop distressing respiratory symptoms early in the course of the disease or even present with respiratory failure or arrest. We describe 14 patients with motor neuron disease who were considered for respiratory support; 11 received such support and all derived significant symptomatic improvement without distressing prolongation of life. Of the 8 patients with typical features of amyotrophic lateral sclerosis, 7 had predominant diaphragm weakness and 1 generalized respiratory muscle weakness; 7 received negative pressure ventilation by cuirass which improved both the quality of sleep and exercise tolerance. Three patients with predominantly bulbar disease had nocturnal apnoea or hypoventilation. Two received no support. One, who also developed diaphragm weakness, was treated by a cuirass, continuous positive airway pressure (CPAP), and later nocturnal intermittent positive pressure ventilation (IPPV). Three patients with progressive muscular atrophy had predominant diaphragm weakness or nocturnal apnoea. These patients received nocturnal CPAP, cuirass or IPPV with symptomatic benefit. This series shows that some pati...Continue Reading

Citations

Dec 5, 2000·Muscle & Nerve·K Boonyapisit, B Katirji
Aug 1, 1996·Journal of the Neurological Sciences·Mamede De CarvalhoM L Luís
Jun 29, 1999·Journal of the Neurological Sciences·K KimuraH Shibasaki
Feb 20, 2002·Journal of Intellectual Disability Research : JIDR·D BuxhoevedenM Casanova
Mar 1, 1995·Psychophysiology·A HarverE S Katkin
Feb 22, 1992·BMJ : British Medical Journal·T O'BrienC Saunders
Aug 3, 1996·BMJ : British Medical Journal·J M Shneerson
Aug 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·P N Leigh, K Ray-Chaudhuri
Apr 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·R ChenC F Bolton
Jan 14, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M I PolkeyP N Leigh
May 23, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M D BradleyR S Howard
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·R S Howard, Craig Davidson
Dec 3, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·P N LeighKing's MND Care and Research Team
Jan 2, 2003·Postgraduate Medical Journal·R S Howard, R W Orrell
Mar 20, 2014·Neurodegenerative Disease Management·Susana Pinto, Mamede de Carvalho
Apr 25, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·António AtalaiaAnabela Pinto
Mar 21, 2006·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Catherine HeffernanMary-Ann Ampong
Apr 5, 2002·Muscle & Nerve·Josep Valls-Solé, Margarita Solans
Jan 1, 1991·Mayo Clinic Proceedings·D B Williams, A J Windebank
Jan 29, 2011·Archives of Physical Medicine and Rehabilitation·Jeanette TamplinDavid J Berlowitz
Jan 1, 1990·Archives of Disease in Childhood·P C NgP R Dear
Sep 8, 1998·The American Journal of Hospice & Palliative Care·J Ewens

Related Concepts

Amyotrophic Lateral Sclerosis, Guam Form
Motor Neurons
Neurogenic Muscular Atrophy
Foley-Denny-Brown Syndrome
Todd Paralysis
Respiration Disorders
Hypersomnia With Periodic Respiration

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.