PMID: 11323786Apr 27, 2001Paper

Respiratory diseases caused by occupational exposure to 1,5-naphthalene-diisocyanate (NDI): Results of workplace-related challenge tests and antibody analyses

American Journal of Industrial Medicine
X BaurB Marczynski

Abstract

1,5-naphthalene-diisocyanate (NDI) is an aromatic diisocyanate with a very low vapor pressure which is mainly used in the automotive industry. In the present study we described five cases with workplace-related asthma and one case with extrinsic allergic alveolitis associated with pulmonary hemorrhage after NDI exposure. Corresponding to case histories, extrinsic alveolitis on asthmatic reactions in three subjects and a rhinitis reaction in one patient could be reproduced by inhalative challenge tests to NDI at a concentration of 10 ppb. Preliminary IgE and IgG antibody analyses in patients' sera did not produce significantly positive results. According to the outcome of our tests and in comparison with several other studies, we conclude that NDI should be classified as potent airway-sensitizing substance. Improved workplace conditions and decrease in threshold limit values should therefore be recommended.

References

Mar 1, 1986·Archives of Environmental Health·R AlexanderssonG Rosen
Sep 1, 1995·Archives of Environmental Health·L J FuortesM Makowsky
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine
Jan 1, 1994·International Archives of Occupational and Environmental Health·X BaurG Fruhmann
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Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

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Citations

Mar 1, 2006·International Archives of Occupational and Environmental Health·C J SennbroH Tinnerberg
May 1, 2012·International Archives of Occupational and Environmental Health·Lygia Therese BudnikXaver Baur
May 30, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Qing Liu, Adam V Wisnewski
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·Giovanni Viegi, Cinzia Di Pede
Mar 5, 2008·Current Opinion in Allergy and Clinical Immunology·Martin J SeedRaymond M Agius

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