Respiratory drive and pulmonary mechanics during haemodialysis with ultrafiltration in ventilated patients

Anaesthesia and Intensive Care
C C HuangR S Lan

Abstract

The improvements of respiratory drive and pulmonary mechanics which follow haemodialysis with ultrafiltration in mechanically ventilated renal failure patients seem predictable but have not been studied before. In this study, 14 renal failure patients with stable haemodynamics mechanically ventilated with pressure support ventilation (PSV) were enrolled. Respiratory drive (represented as P0.1), pulmonary mechanics, breathing pattern, arterial blood gas and haemodynamics were measured according to the time schedule: pre-dialysis (Time 0), and at 60, 120, 180, 240 minutes thereafter. Following the removal of excess lung water during haemodialysis, auto-PEEP and patient's work of breathing (WOBp) decreased gradually. P0.1 lessened progressively along with the improvement in pulmonary mechanics. The changes in auto-PEEP and WOBp correlated closely to the pre- and post-dialysis decline of P0.1 (delta P0.1). There was a negative, moderately significant correlation between the amount of fluid ultrafiltrated during dialysis (delta UF) and the delta P0.1 (R = -0.54). The breathing pattern remained stable during dialysis. No hypoventilation or hypoxaemia occurred despite the development of metabolic alkalosis induced by bicarbonate dialy...Continue Reading

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Citations

Jun 5, 2014·BioMed Research International·Anastasios F PalamidasNikolaos G Koulouris
Jun 28, 2018·Clinical and Experimental Nephrology·Cibele Puato AlmeidaDaniela Ponce
Nov 3, 2006·Critical Care Medicine·José Mauro VieiraDaniel Deheinzelin
Jun 24, 2016·American Journal of Respiratory and Critical Care Medicine·Faeq Husain-SyedClaudio Ronco
Jul 24, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Heather A HaugenFanny Li

Related Concepts

Alkalosis
Anoxemia
Carbonic Acid Ions
Body Fluids
Ampholytes
Carbon Dioxide
Hemodynamics
Hypoventilation
Kidney Failure, Chronic
Lung

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