Respiratory dysfunction is common in patients with achalasia and improves after pneumatic dilation

Digestive Diseases and Sciences
Mahesh GuptaV A Saraswat

Abstract

Dysphagia, regurgitation, and chest pain are common achalasia, with a variable report of pulmonary symptoms possibly due to micro-aspiration. Pneumatic dilation (PD) may improve pulmonary function. Data on pulmonary dysfunction among achalasia patients are scanty, and the effect of PD is unknown. To evaluate pulmonary dysfunction in patients with achalasia based on clinical and radiologic evaluation and spirometry and to study the effect of PD at 1-month follow-up. Patients with achalasia (diagnosed using high-resolution manometry and the Chicago classification) were evaluated prospectively by spirometry before (n = 38) and 1 month after PD (n = 31). All patients received a chest X-ray, and patients with respiratory abnormality before PD received high-resolution computed tomography of the thorax. Of the 38 patients, 17 and 21 had type I and II achalasia, respectively. The respiratory symptoms, such as pharyngeal symptoms [27/38 (71 %) vs. 8/31 (26 %); P = 0.0001], cough [23/38 (60.5 %) vs. 5/31 (16 %), P = 0.0001], and dyspnea [8/38 (21 %) vs. 0/31 (0 %), P = 0.006], improved after treatment with PD. Spirometry showed abnormalities in 17/38 (45 %) patients before and in 8/15 (53 %) after PD. Median FEV(1), FVC, PEFR, and percen...Continue Reading

References

Apr 1, 1978·The Australian and New Zealand Journal of Surgery·S MuralidharanS John
Nov 15, 1979·The New England Journal of Medicine·D O Castell
Jan 1, 1989·Pediatric Pulmonology·S ChapmanR G Buick
Dec 1, 1988·Postgraduate Medical Journal·L S WickramasingheS Ghosh
Oct 1, 1970·The Annals of Otology, Rhinology, and Laryngology·A M Olsen
Aug 1, 1997·AJR. American Journal of Roentgenology·J M de OliveiraM E Baker
Jul 16, 1999·The American Journal of Gastroenterology·M F VaeziJ E Richter
Jun 2, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·T FranquetC Pérez
Oct 12, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ana GiménezPilar Estrada
Feb 11, 2003·Chest·Nikolaos AkritidisKonstantinos Paparounas
Aug 31, 2004·American Journal of Otolaryngology·Burke E Chegar, Precha Emko
Jun 1, 1950·Annals of Internal Medicine·C T BELLOG E FARRAR
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Oct 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P O Katz, J K Lehrer
Jul 26, 2008·Cough·Nighat F MehdiMutasim N Abu-Hasan
Aug 30, 2008·Gastroenterology·John E PandolfinoPeter J Kahrilas
Dec 20, 2008·American Journal of Respiratory and Critical Care Medicine·Edoardo SavarinoMassimo Ghio
Feb 19, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G K MakhariaV Sreenivas
Aug 26, 2009·World Journal of Gastroenterology : WJG·Alexander J Eckardt, Volker F Eckardt
Apr 7, 2010·The American Journal of Medicine·Joyce S LeeTalmadge E King
Nov 16, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H SinanB K Oelschlager
Dec 21, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Saurabh KhandelwalBrant K Oelschlager
Apr 19, 2011·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Tareq Al-Abdoulsalam, Mark A Anselmo
Oct 18, 2011·Internal Medicine·Shin'ichi MiyamotoTsutomu Chiba
Jan 4, 2012·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Uday C GhoshalAsha Misra
Feb 22, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J BredenoordUNKNOWN International High Resolution Manometry Working Group
Jun 22, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Zhiyue LinJ E Pandolfino
Jul 21, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Rajinder ParshadAshu Seith Bhalla
May 15, 2013·Journal of Neurogastroenterology and Motility·Zafar NeyazUday C Ghoshal

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Citations

Jan 23, 2015·World Journal of Surgery·Fernando A M Herbella, Marco G Patti
Jun 11, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Ciro AndolfiMarco G Patti
May 28, 2019·Current Treatment Options in Pediatrics·Lusine AmbartsumyanRachel Rosen
Aug 28, 2019·Digestive Diseases and Sciences·Mitchell S CappellDavid Friedel
Mar 8, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eric Omar ThenVinaya Gaduputi
Feb 3, 2021·Clinical Journal of Gastroenterology·Ryohei AndoTakashi Kamei
Aug 3, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jessica L YasudaRachel Rosen

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