PMID: 6107094Nov 1, 1980Paper

Respiratory effects of a new opiate analgesic, R 39209, in the rabbit: comparison with fentanyl

British Journal of Anaesthesia
J H BrownB Kay

Abstract

The respiratory effects of R 39209, a new short-acting analgesic, were studied and compared with those of fentanyl, in the rabbit. Minute volume, respiratory frequency and pH, PCO2 and standard bicarbonate of arterialized venous blood were measured. R 39209 had an earlier peak effect and shorter duration of action then fentanyl, but otherwise the respiratory effects of the two-drugs were similar. Fentanyl was between 2 and 3.5 times more potent than R 39209. Repeated doses of R 39209 produced reproducible peak effects even when only 10 min was allowed between administrations.

Citations

Sep 1, 1985·Canadian Anaesthetists' Society Journal·D P Cartwright
Jul 1, 1985·Canadian Anaesthetists' Society Journal·J P Dechène
Sep 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A B Enright, J B Parker
Oct 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W A EdginM J Mansfield
Feb 1, 1984·Acta Anaesthesiologica Scandinavica·F L ScammanK Korttila
Feb 1, 1985·Acta Anaesthesiologica Scandinavica·M HynynenA M Lehtinen
Jun 1, 1982·Acta Anaesthesiologica Scandinavica·P A Janssen
Jan 15, 2000·Journal of Neurosurgical Anesthesiology·J P ColesA K Gupta
May 1, 1986·Drug Intelligence & Clinical Pharmacy·J A Reitz

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