Oct 1, 1975

Respiratory effects of H+ and dinitrophenol injections into the brain stem subarachnoid space of fetal lambs

Canadian Journal of Physiology and Pharmacology
A H JansenV Chernick

Abstract

Mock cerebrospinal fluid (pH 5.37-8.38) or 2,4-dinitrophenol (DNP) (0.15-1.5 mg) was injected into the subarachnoid space of the ventral brain stem of exteriorized fetal sheep. Changes in pH on the ventral surface of the medulla did not stimulate respiratory efforts or induce significant cardiovascular changes. The respiratory response to DNP injections ranged from no response to prolonged rhythmic ventilation that was independent of the peripheral chemoreceptors or the control arterial pH and blood gas tensions. This inconsistency suggests an effector site somewhat removed from the immediate surface of the medulla. The heart rate and blood pressure were not affected. It is concluded that increased H+ concentration in the extracellular fluid of the fetal ventral medulla does not initiate respiration, and any respiratory response to metabolic inhibitors applied to this area therefore is not attributable to a secondary change in surface pH.

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Mentioned in this Paper

Arterial Blood pH Measurement
Metabolic Process, Cellular
Dinitrophenols
Fetal Structures
Entire Medulla Oblongata
2,4-Dinitrophenol
Diastolic Blood Pressure
Cell Respiration
Extracellular Fluid
Blood Gas

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