PMID: 3768224Oct 1, 1986Paper

Respiratory effects of nitrous oxide during isoflurane anaesthesia in children

British Journal of Anaesthesia
I MuratK MacGee

Abstract

Respiratory effects of nitrous oxide and isoflurane were studied in 13 children (mean age 45.6 +/- 19.3 months, mean weight 14.9 +/- 4.8 kg) during surgery under continuous extradural anaesthesia. Three different anaesthetic states were studied: isoflurane 0.5 MAC in oxygen (27 study periods), isoflurane 0.5 MAC with 50% nitrous oxide (32), isoflurane 1 MAC in oxygen (25). End-tidal carbon dioxide (PE' CO2) and isoflurane, respiratory indices (tidal volume, VT; minute ventilation, VE; mean inspiratory flow, VI; respiratory frequency f, effective inspiratory timing TI/Ttot were measured. The addition of nitrous oxide (comparison of respiratory variables obtained in 25 successive periods at (1) and (2)) produced a significant increase in PE' CO2' significant decreases in VT, VE and VI, a significant increase in f. The increase in alveolar concentration of isoflurane ((1) compared with (3) in 25 successive periods) was associated with a significant increase in PE' CO2' significant decreases in VT, VE, VI and a significant increase in f. The equipotent anaesthetic states (2) and (3) were compared in 21 successive periods. In children, the net result of substituting nitrous oxide for an equal MAC fraction of isoflurane was to produc...Continue Reading

Citations

Apr 3, 2013·Pediatric Emergency Care·Joseph D Tobias
Dec 11, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R S LitmanD S Ward
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·I MuratC Saint-Maurice

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