Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease.

American Journal of Respiratory Cell and Molecular Biology
Jerry M WrightMichael P Boyle

Abstract

Despite having identical cystic fibrosis transmembrane conductance regulator genotypes, individuals with DeltaF508 homozygous cystic fibrosis (CF) demonstrate significant variability in severity of pulmonary disease. This investigation used high-density oligonucleotide microarray analysis of nasal respiratory epithelium to investigate the molecular basis of phenotypic differences in CF by (1) identifying differences in gene expression between DeltaF508 homozygotes in the most severe 20th percentile of lung disease by forced expiratory volume in 1 s and those in the most mild 20th percentile of lung disease and (2) identifying differences in gene expression between DeltaF508 homozygotes and age-matched non-CF control subjects. Microarray results from 23 participants (12 CF, 11 non-CF) met the strict quality control guidelines and were used for final data analysis. A total of 652 of the 11,867 genes identified as present in 75% of the samples were significantly differentially expressed in one of the three disease phenotypes: 30 in non-CF, 53 in mild CF, and 569 in severe CF. An analysis of genes differentially expressed by severity of CF lung disease demonstrated significant upregulation in severe CF of genes involved in protein ...Continue Reading

References

Nov 1, 1992·American Journal of Respiratory Cell and Molecular Biology·E PuchelleW Dalemans
Jan 1, 1989·Life Sciences·B L Shapiro
Dec 17, 1981·The New England Journal of Medicine·M KnowlesR Boucher
Jun 22, 1999·Infection and Immunity·A M ColeT Ganz
Jun 6, 2000·American Journal of Respiratory Cell and Molecular Biology·A J Ratner, A Prince
Jul 25, 2000·The Journal of Biological Chemistry·T Yao, R E Cohen
May 9, 2001·The Journal of Pediatrics·G M NixonK Grimwood
Jul 21, 2001·Twin Research : the Official Journal of the International Society for Twin Studies·F MekusB Tümmler
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Andrew I SuJohn B Hogenesch
Jul 12, 2002·Statistics in Medicine·Mark D SchluchterPamela B Davis
Dec 17, 2002·The Journal of Biological Chemistry·Yan XuJeffrey A Whitsett
Mar 11, 2003·American Journal of Respiratory Cell and Molecular Biology·Corinne Wijkstrom-FreiGregory E Conner
Apr 5, 2003·The Journal of Laboratory and Clinical Medicine·Christian A Merlo, Michael P Boyle
Apr 19, 2003·Genome Biology·Barry R ZeebergJohn N Weinstein
May 6, 2003·European Journal of Immunology·Rivkah GonskyStephan R Targan
Jun 6, 2003·Biochemical and Biophysical Research Communications·A OhashiN Katunuma
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Miklós GeisztThomas L Leto
Feb 12, 2004·Archives of Biochemistry and Biophysics·David M KrzywanskiHenry Jay Forman
Apr 27, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shuo ZhengSerpil C Erzurum
Sep 17, 2004·Biochemical and Biophysical Research Communications·Anna M WolfHerbert Tilg
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·L P A McGarveyJ S Elborn
Oct 14, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·V Cuneyt KalfaAlexander M Cole
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshinari TanabeMichael David
Jan 29, 2005·American Journal of Respiratory Cell and Molecular Biology·Radia FortezaGregory E Conner
Mar 17, 2005·The Biochemical Journal·Gordon B ProctorPeter Wilde
May 27, 2005·Biochemical Society Transactions·J Hirst
Jun 7, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joseph ZabnerPaul B McCray

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Citations

Feb 23, 2010·Nature Genetics·Michael H ChoEdwin K Silverman
Apr 1, 2009·Antioxidants & Redox Signaling·Brian GriffithVictor J Thannickal
Jan 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas H Hampton, Bruce A Stanton
May 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Arnaud ChambellanSerpil C Erzurum
Jan 5, 2007·Proceedings of the American Thoracic Society·Michael P Boyle
Oct 24, 2012·EMBO Molecular Medicine·Annerose BerndtSteven D Shapiro
Oct 25, 2011·Annual Review of Pathology·Mitchell L DrummPamela B Davis
Oct 16, 2012·Progress in Neurobiology·Rory JohnsonNoel J Buckley
Mar 15, 2011·Biochimica Et Biophysica Acta·Albert van der Vliet
Nov 17, 2009·Trends in Molecular Medicine·Abdelmounaaïm AllaouiXavier De Deken
Jan 1, 2008·Free Radical Biology & Medicine·Albert van der Vliet
Aug 28, 2015·Scientific Reports·Iwona Ziółkowska-SuchanekJerzy Nowak
Jul 5, 2012·Annals of the New York Academy of Sciences·Jason P EiserichCarroll E Cross
Dec 18, 2013·Pediatric Pulmonology·Neil B Sweezey, Felix Ratjen
May 31, 2011·Journal of Proteomics·Tânia SimõesDeborah Penque
Mar 19, 2014·The International Journal of Biochemistry & Cell Biology·Paul J McKiernanCatherine M Greene
Feb 18, 2015·Epigenomics·Anne BergougnouxAlbertina De Sario
Jun 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Beth MalcomsonBettina C Schock
Oct 26, 2016·Chemistry and Physics of Lipids·Massimo AureliSandro Sonnino
Aug 31, 2017·American Journal of Respiratory and Critical Care Medicine·Deepika PolineniMichael R Knowles
May 2, 2018·Annual Review of Genomics and Human Genetics·Wanda K O'Neal, Michael R Knowles
May 30, 2019·Pediatric Pulmonology·Shivanthan ShanthikumarSarath Ranganathan
Jul 12, 2014·Journal of Physical Therapy Science·Fernando Silva GuimarãesSara Lúcia Silveira de Menezes
Jul 10, 2019·Scientific Reports·Yunjie HuangAnjaparavanda P Naren
Mar 16, 2017·Clinical Epigenetics·Milena MagalhãesAlbertina De Sario
Dec 29, 2020·Pediatric Pulmonology·İlksen Berfin EkinciDidem Dayangaç-Erden
Jan 27, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Marc A SalaPaul A Reyfman
Jan 14, 2021·Molecular Systems Biology·Noam AuslanderEytan Ruppin

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