Respiratory flow characteristics during isoflurane/nitrous oxide anaesthesia

Acta Anaesthesiologica Scandinavica
L O Jonsson, C Wahlgreen

Abstract

Ventilatory characteristics during isoflurane anaesthesia and spontaneous breathing were studied in ten adults during surgery. After premedication with diazepam and induction with thiopental sodium and suxamethonium, 1.2% isoflurane in a 50% mixture of nitrous oxide in oxygen was introduced via a non-rebreathing circuit. Respiratory flow was measured by means of a pneumotachograph, arterial gases were sampled and carbon dioxide elimination and dead-space to tidal volume ratios (VD/VT) calculated. The time axis of one respiratory cycle was divided into 20 equidistant sections and the flow at the end of each section was expressed as a percentage of the maximum flow rate during inspiration and expiration, respectively. In this manner, a relative respiratory flow pattern was constructed. The total ventilation was 5.8 +/- 0.5 1.min-1 (mean +/- s.d.) with a tidal volume of 191 +/- 45 ml and a respiratory rate of 31 +/- 6.min-1. The PaCO2 was 7.2 +/- 0.6 kPa, the carbon dioxide elimination 151 +/- 38 ml (STPD) and VD/VT 0.53 +/- 0.12. The respiratory flow pattern showed early peak flows during both inspiration and expiration. The expiratory flow rate after 90% of the total respiratory cycle time was on average 43% of the maximum expir...Continue Reading

References

May 1, 1978·Anaesthesia and Intensive Care·W J Russel
Apr 1, 1987·British Journal of Anaesthesia·W S WrenP O'Griofa
Sep 1, 1987·British Journal of Anaesthesia·K AlagesanC P Heneghan
Feb 1, 1987·Acta Anaesthesiologica Scandinavica·L O Jonsson, H Zetterström
Feb 1, 1987·Acta Anaesthesiologica Scandinavica·L O JonssonH Zetterström
Apr 1, 1985·Acta Anaesthesiologica Scandinavica·L O Jonsson, H Zetterström
Jul 1, 1971·Anesthesiology·H E FourcadeE I Eger
Dec 1, 1983·British Journal of Anaesthesia·B KayM Calpin
Nov 1, 1981·Anesthesiology·E I Eger
Oct 1, 1981·Acta Anaesthesiologica Scandinavica·S LindhalA K Olsson

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