Respiratory gas exchange by high-efficiency hemodialyzers

Nephron
N TolchinE J Lewis

Abstract

The effects of respiratory gas mass-transfer by high-efficiency hemodialyzers with regard to respiratory status and acid-base balance were studied in three groups of patients. Patients dialyzed with acetate dialysate and a single pass delivery system (group I) and those dialyzed with the same dialysate and a recirculating single pass system (group II) had significant intradialytic decreases in PCO2 (p is less than 0.05), while patients hemodialyzed aginst a carbon dioxide/bicarbonate dialysate (group III) had no significant alterations in arterial PCO2. The massfransfer rate of carbon dioxide was 0.3 mM/min in group I and 0.2 mM/min in group II. The hypocapnia caused by dialyzer mass-transfer of carbon dioxide was associated with a significant drop in minute ventilation volume and a decrease in PO2 which was significant in group I (p is less than 0.05). Although bicarbonate mass-transfer reduced serum bicarbonate levels, the loss of carbon dioxide to the dialysate resulted in an increased arterial pH during dialysis.

Citations

Jul 9, 1981·The New England Journal of Medicine·M J DolanK Wasserman
Nov 26, 1981·The New England Journal of Medicine
Nov 1, 1982·Artificial Organs·W D DavidsonK Wasserman
Feb 1, 1986·Artificial Organs·S Ringoir, R Vanholder
Jun 1, 1990·Artificial Organs·M MorosettiC U Casciani
Jul 30, 1983·British Medical Journal·M A Mansell, A J Wing
May 1, 1984·The Journal of Clinical Investigation·D D RalphM P Hlastala
Jun 1, 1993·The Journal of Clinical Investigation·V S LimS T Sum-Ping
Sep 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A R Eiser
Jan 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M Diamond, W L Henrich
Feb 1, 1982·Kidney International·L L HammT D DuBose
Apr 1, 1992·Kidney International·T SymrengV S Lim
May 1, 1983·Kidney International·W A De BackerM E De Broe
Sep 1, 1995·Scandinavian Journal of Urology and Nephrology·N LøkkegaardP B Brekke
Jan 1, 1980·Journal of Dialysis·J ShinM Nishioka

Related Concepts

Acetic Acids
Anion Gap
Carbonic Acid Ions
Blood Gas Analysis
Carbon Dioxide
Hemodialysis
Kidney Failure, Chronic
Dioxygen
Respiration

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.