Respiratory-gated imaging in metabolic evaluation of small solitary pulmonary nodules: 18F-FDG PET/CT and correlation with histology

Nuclear Medicine Communications
Karim FaridSlavomir Petras

Abstract

The aim of the study was to evaluate the effect of 2-((18)F)-fluoro-2-deoxy-D-glucose ((18)F-FDG)-PET/computed tomography (CT) respiratory-gated imaging [four-dimensional (4D)] in the metabolic evaluation of small solitary pulmonary nodules and analyze the cutoff maximum standardized uptake value (SUV(max)) of 2.5 in classifying and distinguishing benign/malignant pulmonary pathologies in 4D studies. Thirty-two patients with pulmonary lesions measuring 2 cm or less were included during their scheduled (18)F-FDG PET/CT examinations. The whole-body PET/CT acquisition (3D) was followed by a chest-centered PET/CT (4D) study synchronized with the respiratory cycle. The SUV(max) percentage difference (%Diff SUV(max)) was calculated. The nodule size, localization, and relationships with histological/cytological findings were studied. Fifteen nodules were 10 mm or smaller and 17 were larger than 10 mm [mean size = 12 mm (7-20)]. The mean 3D-SUV(max) was 2.5 (0.7-6.1) and the mean 4D-SUV(max) 3.2 (0.9-7.2) (P < 0.001). The mean %Diff SUV(max) was 38% for all patients (7-90), 45% in subcentimetric (7-90%) and 31% (7-75%) in supracentimetric lesions (P = NS). Histology was obtained in 23/32 (72%) cases and the pathologic benign/malignant ...Continue Reading

References

Apr 1, 1993·Mayo Clinic Proceedings·D E MidthunJ R Jett
Nov 4, 1998·Seminars in Nuclear Medicine·A Al-Sugair, R E Coleman
Jun 4, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Gerarda J HerderEgbert F Smit
Jun 23, 2004·Nuclear Medicine Communications·D VisvikisC Cheze-Le Rest
Jan 30, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Angela van BaardwijkDirk De Ruysscher
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Apr 9, 2008·Seminars in Nuclear Medicine·David W Townsend
Apr 9, 2008·Seminars in Nuclear Medicine·Sadek A Nehmeh, Yusuf E Erdi
Feb 20, 2009·Annals of Nuclear Medicine·Andrea LupiPierluigi Zanco
Mar 31, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hugo J W L AertsDirk De Ruysscher
Dec 4, 2009·Frontiers of Radiation Therapy and Oncology·Richard P BaumVikas Prasad
Feb 1, 2011·The Lancet Oncology·William Pao, Nicolas Girard
Feb 1, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Adam Leon Kesner
Feb 22, 2014·AJR. American Journal of Roentgenology·Anna Margherita MaffioneDomenico Rubello

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Citations

Oct 7, 2017·Nuclear Medicine Communications·Pascal BaillyJoël Daouk
Jan 18, 2018·The British Journal of Radiology·Russell FroodAndrew Scarsbrook
Oct 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lino Morris SawickiPhilipp Heusch
Mar 19, 2020·Current Radiopharmaceuticals·Cinzia Crivellaro, Luca Guerra

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Methods Mentioned

BETA
surgical resection
imaging procedure
biopsy

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