Respiratory gated PET/CT in a European multicentre retrospective study: added diagnostic value in detection and characterization of lung lesions.

European Journal of Nuclear Medicine and Molecular Imaging
Luca GuerraCristina Messa

Abstract

The aim of our work is to evaluate the added diagnostic value of respiratory gated (4-D) positron emission tomography/computed tomography (PET/CT) in lung lesion detection/characterization in a large patient population of a multicentre retrospective study. The data of 155 patients (89 men, 66 women, mean age 63.9 ± 11.1 years) from 5 European centres and submitted to standard (3-D) and 4-D PET/CT were retrospectively analysed. Overall, 206 lung lesions were considered for the analysis (mean ± SD lesions dimension 14.7 ± 11.8 mm). Maximum standardized uptake values (SUV(max)) and lesion detectability were assessed for both 3-D and 4-D PET/CT studies; 3-D and 4-D PET/CT findings were compared to clinical follow-up as standard reference. Mean ± SD 3-D and 4-D SUV(max) values were 5.2 ± 5.1 and 6.8 ± 6.1 (p < 0.0001), respectively, with an average percentage increase of 30.8 %. In 3-D PET/CT, 86 of 206 (41.7 %) lesions were considered positive, 70 of 206 (34 %) negative and 50 of 206 (24.3 %) equivocal, while in 4-D PET/CT 117 of 206 (56.8 %) lesions were defined as positive, 80 of 206 (38.8 %) negative and 9 of 206 (4.4 %) equivocal. In 34 of 50 (68 %) 3-D equivocal lesions follow-up data were available and the presence of maligna...Continue Reading

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Citations

Jun 19, 2013·European Journal of Radiology·Yuko SuenagaKazuro Sugimura
Oct 4, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Marco SpadaforaLuigi Mansi
Jun 7, 2017·European Journal of Radiology·Marco SpadaforaAlberto Cuocolo
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Aug 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Cinzia CrivellaroLuca Guerra
Aug 13, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Adam Leon Kesner
Oct 7, 2017·Nuclear Medicine Communications·Pascal BaillyJoël Daouk
Nov 3, 2017·Medical Physics·Adam L KesnerDavid A Lynch
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May 26, 2021·Medical Physics·David G BlackIvan S Klyuzhin
Mar 19, 2020·Current Radiopharmaceuticals·Cinzia Crivellaro, Luca Guerra
Jun 9, 2021·Physics in Medicine and Biology·Andre Z Kyme, Roger R Fulton

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