Respiratory gating enhances imaging of pulmonary nodules and measurement of tracer uptake in FDG PET/CT

AJR. American Journal of Roentgenology
Matthias K WernerMatthew R Palmer

Abstract

The aim of this study was to evaluate prospectively the effects of respiratory gating during FDG PET/CT on the determination of lesion size and the measurement of tracer uptake in patients with pulmonary nodules in a clinical setting. Eighteen patients with known pulmonary nodules (nine women, nine men; mean age, 61.4 years) underwent conventional FDG PET/CT and respiratory-gated PET acquisitions during their scheduled staging examinations. Maximum, minimum, and average standardized uptake values (SUVs) and lesion size and volume were determined with and without respiratory gating. The results were then compared using the two-tailed Student's t test and the nonparametric Wilcoxon's test to assess the effects of respiratory gating on PET acquisitions. Respiratory gating reduced the measured area of lung lesions by 15.5%, the axial dimension by 10.3%, and the volume by 44.5% (p = 0.014, p = 0.007, and p = 0.025, respectively). The lesion volumes in gated studies were closer to those assessed by standard CT (difference decreased by 126.6%, p = 0.025). Respiratory gating increased the measured maximum SUV by 22.4% and average SUV by 13.3% (p < 0.001 and p = 0.002). Our findings suggest that the use of PET respiratory gating in PET/...Continue Reading

References

Feb 26, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Karoline SpaepenChristine De Wolf-Peeters
Mar 5, 2003·Radiology·Gerhard W GoerresGustav K Von Schulthess
Oct 11, 2003·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ursula NestleCarl Martin Kirsch
Dec 25, 2003·JAMA : the Journal of the American Medical Association·Gerald AntochStefan G Ruehm
Jul 21, 2004·Medical Physics·S A NehmehJ L Humm
Jan 18, 2005·Medical Physics·S A NehmehJ L Humm
Oct 24, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ursula NestleCarl-Martin Kirsch
Dec 21, 2006·AJR. American Journal of Roentgenology·Yeong Joo JeongKyung Soo Lee
Jan 31, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Weibo CaiXiaoyuan Chen
Apr 5, 2007·Nature Protocols·Suren SoghomonyanMian M Alauddin
May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Claude NahmiasDavid W Townsend
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marine SoretIrène Buvat
Oct 6, 2007·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Jul 16, 2008·Acta Oncologica·Stine S KorremanLena Specht
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tsuyoshi KawanoTomio Inoue
Oct 7, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthias GuckenbergerMichael Flentje
Mar 28, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Barbara J FuegerMartin S Allen-Auerbach
Nov 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aleksandar GrgicDirk Hellwig

❮ Previous
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Citations

Jul 24, 2010·Der Radiologe·C KratochwilF L Giesel
Jun 26, 2010·European Radiology·A LakkarajuA F Scarsbrook
Dec 20, 2013·Nuclear Medicine Communications·Audrey PépinMarc-Etienne Meyer
Feb 9, 2012·International Journal of Surgical Oncology·Owen J O'ConnorMichael A Blake
Jul 26, 2013·AJR. American Journal of Roentgenology·Matthew KruseRathan M Subramaniam
Feb 22, 2014·AJR. American Journal of Roentgenology·Anna Margherita MaffioneDomenico Rubello
May 17, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Luca GuerraCristina Messa
Jul 20, 2011·Acta Oncologica·Ingerid Skjei KnudtsenEirik Malinen
Jun 9, 2015·Seminars in Nuclear Medicine·Paul FlechsigFrederik L Giesel
Jan 21, 2014·Journal of Medical Imaging and Radiation Oncology·Abdel K TahariRichard L Wahl
May 15, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthew R McCurdyThomas Guerrero
Jun 28, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alin ChirindelUrsula Nestle
Apr 9, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Benedikt SchaarschmidtPhilipp Heusch
Jun 19, 2013·European Journal of Radiology·Yuko SuenagaKazuro Sugimura
Mar 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·Alessandro BaisiUgo Cioffi
Mar 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·Morihito OkadaYoshihiro Miyata
Oct 12, 2016·Radiología·L Pelegrí MartínezJ L Vercher Conejero
May 4, 2016·Radiologia brasileira·Marcos Pretto MosmannKenio Costa de Lima
Aug 22, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Cinzia CrivellaroLuca Guerra
Nov 10, 2012·Acta Radiologica·Yoshiyuki TakahashiMasahiko Higashiyama
Sep 2, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyun Woo Goo, Thomas Allmendinger
Nov 22, 2019·Current Radiopharmaceuticals·Riccardo LaudicellaAndrei Iagaru
Aug 14, 2012·Journal of Medical Imaging and Radiation Oncology·Laura EvangelistaRoberta Polverosi
Jan 18, 2018·The British Journal of Radiology·Russell FroodAndrew Scarsbrook
Oct 23, 2018·Nuclear Medicine and Molecular Imaging·Sungwoo BaeWon Woo Lee
Nov 14, 2020·International Journal of Radiation Oncology, Biology, Physics·Tinsu PanDershan Luo

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