PMID: 6159330Jan 1, 1980Paper

Respiratory hypersensitivity to Ascaris extract in guinea pigs sensitized by aerosol

International Archives of Allergy and Applied Immunology
W A CainJ H Wells

Abstract

Guinea pigs exposed via the respiratory route to Ascaris suum extract in aerosol form became hypersensitive. The hypersensitivity was detectable by inhalational bronchial provocation testing using a noninvasive plethysmography, by chopped lung histamine release, and by passive cutaneous anaplylaxis. The antibody responsible for the hypersensitivity seems to be directly associated with pulmonary tissue. A locally produced cytotropic pulmonary antibody, probably IgG or IgE may be causal. Histopathology included only a moderate pulmonary eosinophilia. Individual variability in susceptibility to experimental allergic asthma may be controlled by both physiologic and immunologic reactivities.

Citations

Jan 1, 1982·Lung·A Wanner, W M Abraham
May 24, 2011·Prostaglandins & Other Lipid Mediators·Takeshi NabeShigekatsu Kohno
Apr 28, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Morton Lomask
Jun 16, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J BarbaraF Leynadier

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