Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: a comparison of endpoints

Journal of Applied Toxicology : JAT
Jürgen PauluhnHans-Werner Vohr

Abstract

A rat bioassay has been developed to provide an objective approach for the identification and classification of respiratory allergy using trimellitic anhydride (TMA), which is a known respiratory tract irritant and asthmagen. Particular emphasis was placed on the study of route-of-induction-dependent effects and their progression upon inhalation challenge with TMA (approximately 23 mg m(-3) for a duration of 30 min), which included analysis of specific and non-specific airway hyperreactivity and pulmonary inflammation initiated and sustained by immunological processes. Refinement of the bioassay focused on procedures to probe changes occurring upon challenge with TMA or methacholine aerosols using physiological, biochemical and immunological procedures. Following challenge with TMA, the rats sensitized to TMA showed marked changes in peak inspiratory and expiratory air flows and respiratory minute volume. In these animals, a sustained pulmonary inflammation occurred, characterized by specific endpoints determined in bronchoalveolar lavage (lactate dehydrogenase, protein, nitrite, eosinophil peroxidase, myeloperoxidase). When compared with the naive controls, lung weights were increased significantly, as were the weights of lung...Continue Reading

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Citations

Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Xing-Dong ZhangPaul D Siegel
Apr 5, 2003·Toxicology Letters·Josje H E Arts, C Frieke Kuper
May 23, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jürgen Pauluhn
Nov 26, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ian KimberRebecca J Dearman
Sep 7, 2011·Toxicology·C Frieke KuperJosje H E Arts
Nov 21, 2007·Toxicology and Applied Pharmacology·Darrell R BoverhofMichael R Woolhiser
Apr 9, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jürgen Pauluhn, Ulrich Mohr
May 13, 2015·Toxicology·Stella A CochraneIan Kimber
Dec 3, 2014·Regulatory Toxicology and Pharmacology : RTP·Juergen Pauluhn, Keisuke Ozaki
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Josje H E Arts, C Frieke Kuper
Jul 1, 2020·Clinical Reviews in Allergy & Immunology·Debajyoti Ghosh, Jonathan A Bernstein
Jun 15, 2007·Alternatives to Laboratory Animals : ATLA·Ian KimberUNKNOWN European Centre for the Validation of Alternative Methods
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer
Oct 30, 2008·Journal of Immunotoxicology·Jean F Regal

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