Respiratory infection with attenuated Mycobacterium tuberculosis H37Ra in malnourished guinea pigs.

Infection and Immunity
David N McMurrayP A Cumberland

Abstract

Specific pathogen-free guinea pigs were infected via the respiratory route with viable, attenuated Mycobacterium tuberculosis H37Ra and maintained on purified isocaloric diets. The control diet contained 30% protein (ovalbumin) and 50 ppm of added zinc (50 micrograms/g), the low protein diet contained 10% protein and 50 ppm of added zinc, and the low zinc diet contained 30% protein and no added zinc. Guinea pigs from each diet treatment were skin tested with purified protein derivative 48 h before sacrifice at 3, 4, and 5 weeks postinfection. Protein-deficient animals exhibited significantly reduced body weight, spleen weight, serum total proteins, and serum albumin. Zinc deficiency was characterized by loss of weight and progressive reductions in plasma zinc concentrations. The number of viable M. tuberculosis H37Ra cells was significantly higher in the lungs of both malnourished groups at 3 weeks, but fell below control viable counts by 5 weeks postinfection. A similar pattern was seen in the spleens and bronchotracheal lymph nodes. Both the proportion and intensity of delayed hypersensitivity reactions increased steadily between 3 and 5 weeks in control animals, whereas the two malnourished groups were essentially anergic at...Continue Reading

References

Nov 19, 1977·Lancet·M H GoldenB E Golden
Sep 1, 1979·American Journal of Diseases of Children·J M OleskeA Nahmias
Jan 1, 1979·Developmental and Comparative Immunology·R S BeachL S Hurley
Aug 1, 1977·The Journal of Nutrition·J C AlbertsG M Briggs
Oct 1, 1978·Clinical Immunology and Immunopathology·T R Kramer, R A Good
Mar 1, 1977·American Journal of Clinical Pathology·J D BogdenJ S Salaki
Oct 9, 1965·Lancet·P S Harland
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·L KarlC F Zukoski
Dec 1, 1973·The Journal of Infectious Diseases·D W Smith
Apr 1, 1971·The Journal of Infectious Diseases·G B Mackaness
Sep 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·L D McBeanJ A Halsted
Jun 1, 1981·Annals of Tropical Paediatrics·J S EdirisingheG A Targett
Feb 1, 1983·Infection and Immunity·D N McMurray, E A Yetley
May 1, 1980·Infection and Immunity·M J Lefford
Jun 1, 1980·Infection and Immunity·E J Wing, J B Young
Aug 1, 1981·Annals of Internal Medicine·J I AllenC J McClain
Feb 1, 1982·The American Journal of Clinical Nutrition·W R Beisel
Jan 1, 1982·The Journal of Nutrition·D N McMurray, E A Yetley
Nov 1, 1981·Infection and Immunity·G J JakabC L Astry
Jan 1, 1980·Chest·D N McMurray
Jan 1, 1981·The American Journal of Clinical Nutrition·D N McMurrayR Miranda

❮ Previous
Next ❯

Citations

Oct 4, 2012·The Journal of Infectious Diseases·Devan Jaganath, Ezekiel Mupere
Jan 1, 1986·Medical Microbiology and Immunology·M A CarlomagnoD N McMurray
Sep 13, 2008·American Journal of Respiratory Cell and Molecular Biology·Richard F SilverJoseph P Sypek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.