Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC).

FEMS Immunology and Medical Microbiology
Kimberly M RothAbhay R Satoskar

Abstract

Francisella tularensis causes pulmonary tularemia and death in humans when left untreated. Here, using a novel aerosol infection model, we show that acute pulmonary Francisella novicida infection not only causes pneumonia and liver damage, but also induces dystrophic cardiac calcinosis (DCC) in BALB/c mice. C57BL/6 mice also develop pneumonia and hepatic damage, but fail to develop DCC. Development of DCC in BALB/c mice is associated with significant induction of RANKL but not osteopontin in their organs. Depletion of lung macrophages prior to infection markedly reduces pericarditis and calcification in BALB/c mice but does not increase their susceptibility to infection.

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Citations

May 25, 2011·The Journal of Infectious Diseases·Gerritje J W van der WindtTom van der Poll
Oct 24, 2019·Memórias do Instituto Oswaldo Cruz·Manoel Marques E OliveiraRosely Maria Zancopé-Oliveira
Feb 13, 2021·Pathogens·David Jiao ZhengBryan Heit

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