Respiratory infections and asthma: current treatment strategies

Drug Discovery Today
Miles Weinberger

Abstract

Infections such as lower respiratory illness potentially contribute to the initiation of asthma and are major factors in recurring acute exacerbations of the condition. Although typical bacterial respiratory pathogens such as Streptococcus pyogenes, Streptococcus pneumoniae and Hemophilus influenzae do not initiate asthmatic exacerbations, data from a subgroup of adults suggest a potential role for Mycoplasma pneumoniae and Chlamydia pneumoniae in the onset of asthma. Common cold viruses, predominantly respiratory syncytial virus (RSV) in young children and rhinoviruses in older children and adults, are the major causes of acute exacerbations of asthma. These exacerbations are not prevented with maintenance therapies that are used for chronic asthma, but do respond to short courses of systemic corticosteroids. There are continued attempts to produce a successful vaccine and antiviral agents for the treatment of RSV that are more effective and more practical to use than ribavirin, which is currently the only available antiviral for RSV. The prevention and treatment of rhinovirus infections have focused on the major receptor for the virus, intercellular adhesion molecule-1 (ICAM-1), which is located on respiratory epithelial cell...Continue Reading

References

Jul 1, 1988·Antiviral Research·F G HaydenR J Colonno
Jun 1, 1986·American Journal of Diseases of Children·W P GlezenJ A Kasel
Jan 21, 1974·JAMA : the Journal of the American Medical Association·T E MinorC E Reed
Apr 1, 1981·The Journal of Pediatrics·D GurwitzH Levison
May 13, 1995·BMJ : British Medical Journal·S L JohnstonD A Tyrrell
Oct 16, 1993·BMJ : British Medical Journal·K G NicholsonD C Ireland
Jan 1, 1996·The European Respiratory Journal·R E DalesJ Boulet
Oct 6, 2001·Vaccine·P J OpenshawW Olszewska

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Citations

Oct 20, 2009·Chest·Jennifer K QuintJadwiga A Wedzicha
Jul 1, 2006·Treatments in Respiratory Medicine·Arne Simon, Oliver Schildgen
Jun 22, 2007·Acta Neuropathologica·Ellen BoelenHarry W M Steinbusch
Sep 9, 2009·Expert Review of Anti-infective Therapy·Matti Korppi
Jan 1, 2006·Expert Review of Clinical Immunology·Weidong ZhangShyam S Mohapatra
Sep 11, 2008·Revista portuguesa de pneumologia·J Pinto Mendes
Mar 7, 2007·Allergologia et immunopathologia·M João SilvaA Bonito Vítor
Dec 5, 2006·The Journal of Allergy and Clinical Immunology·Nino KhetsurianiW Gerald Teague
Feb 23, 2007·The European Journal of Neuroscience·E BoelenF R M Stassen
Mar 1, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R KuoLeeW Chen
Apr 3, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Srirupa MukhopadhyayTapan K Mukherjee
Apr 20, 2006·Neurobiology of Aging·Ellen BoelenFrank R M Stassen
Apr 24, 2014·Interdisciplinary Perspectives on Infectious Diseases·Tuula A Peñate MedinaPaavo K J Kinnunen
Nov 1, 2005·Drug Discovery Today·Fred Del VecchioRobert T Sarisky
May 19, 2012·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Osman Yusuf
Dec 29, 2017·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Caleb D WasserSharon R Smith
Aug 29, 2006·British Journal of Nursing : BJN·Maggi Banning
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaomin WangChung-Wai Chow
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandra Shekhar BakshiTimothy J Sellati

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