PMID: 7014806May 1, 1981Paper

Respiratory infections in infants on mechanical ventilation: the immune response as a diagnostic aid

The Journal of Pediatrics
G P GiacoiaP Ogra

Abstract

A prospective study was undertaken in 41 newborn infants receiving artificial respiration for evaluation of the incidence of respiratory infections. Clinical and radiologic evidence of pneumonia was compared with the appearance of serum antibodies against antigens prepared from microorganisms isolated from bronchial aspirates, and with serum and bronchial immunoglobulin M values. A significant specific immune response was documented in 24% of the patients studied. The data indicate that by correlating the clinical and radiographic findings with specific antibodies and IgM antibody responses, it is possible to document a significant number of respiratory infections. One implication of this study is that subclinical infections may not be uncommon. The significance of the presence and changes in concentration of IgM in bronchial aspirate requires further study.

References

Oct 1, 1978·The Journal of Clinical Investigation·E C LawrenceP M Stevens
Mar 1, 1970·The Journal of Infectious Diseases·E DiazE Neter
May 8, 1980·The New England Journal of Medicine·S StagnoC A Alford
Aug 1, 1965·American Journal of Public Health and the Nation's Health·E NETERA M DRISLANE

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Citations

May 1, 1994·Early Human Development·S Bohin, D J Field

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