PMID: 7372513Mar 1, 1980Paper

Respiratory mechanics and timing during sleep in occlusive sleep apnea

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
R J MartinR M Rogers

Abstract

Six human obese subjects with the sleep apnea hypersomnolence syndrome associated with upper airway occlusion (UAO) were studied during sleep to characterize respiration. Measurements included the timing components of ventilation, pulmonary resistance, flow, and esophageal and gastric pressures before and during UAOs. During the period between UAOs, the resistance progressively increased (9.4-18.1 cmH2O/l(-1) . s, P less than 0.05) as the ventilation decreased (1.82-0.77 l/s, P less than 0.05), but without changes in esophageal pressure swings. During this period, inspiratory time-to-total cycle time decreased (0.42-0.25 s, P less than 0.05) due to expiratory phase prolongation. The apnea began after expiration and terminated on inspiration with the maximal swings in esophageal and gastric pressure near the termination. During the UAO, the respiratory cycle time decreased slightly, but the expiratory pause time was significantly shortened immediately before ventilation. We suggest that the UAO is but one aspect of this syndrome and that a decrease in central nervous system activity diminishes the respiratory drive before the onset of the UAO.

Citations

Feb 1, 1987·Journal of the American Geriatrics Society·D L BliwiseW C Dement
Aug 23, 2007·Journal of Intensive Care Medicine·Maxwell P Kwaku, Kenneth D Burman
Mar 20, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S KuribayashiM Mori
Nov 1, 1992·The American Review of Respiratory Disease·D GeorgopoulusN R Anthonisen
Nov 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·S Chokroverty, J T Sharp
Jan 1, 1989·European Journal of Pediatrics·D P SouthallJ O Warner
Mar 24, 2005·Sleep & Breathing = Schlaf & Atmung·José Haba-RubioJean Krieger
Sep 29, 2012·Journal of Applied Physiology·Sarah A ImmanuelMathias Baumert

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