Respiratory, metabolic, and acid-base correlates of aerobic metabolic rate reduction in overwintering frogs

The American Journal of Physiology
P H DonohoeR G Boutilier

Abstract

Aerobic metabolic rates (MO2) and respiratory quotients (RQ = CO2 production/MO2) were measured contemporaneously in hibernating frogs Rana temporaria (L.), submerged for 90 days at 3 degrees C. After 3 mo of submergence in fully aerated water, MO2 levels were 61% of those seen at the same temperature before hibernation. Over the first 40 days of hibernation, RQ values (< or = 0.82) favored a lipid-based metabolism that progressively shifted to an exclusively carbohydrate metabolism (RQ = 1.01) by 90 days of hibernation. Liver glycogen concentrations fell by 68% during the first 8 wk of submergence, thereafter exhibiting a less rapid rate of utilization. Conversely, muscle glycogen concentrations remained stable over the first 2 mo of the experiment before falling by 33% over the course of the remaining 2 mo, indicating that the frog was recruiting muscle glycogen reserves to fuel metabolism. Submerged frogs exhibited an extracellular acidosis during the first week of submergence, but over the course of the next 15 wk "extracellular pH" values were not significantly different from the values obtained from the control air-breathing animals. The initial extracellular acidosis was not mirrored in the intracellular compartment, and...Continue Reading

References

Jun 1, 1990·The Quarterly Review of Biology·K B Storey, J M Storey
Jan 17, 1986·Science·P W Hochachka
Mar 1, 1988·Metabolism: Clinical and Experimental·E Ferrannini
Feb 1, 1974·Comparative Biochemistry and Physiology. A, Comparative Physiology·S Pasanen, P Koskela
Oct 1, 1971·Journal of Applied Physiology·J N Cameron
Oct 1, 1994·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M GuppyJ E Flanigan
May 1, 1993·The Journal of Experimental Zoology·J S WasserS J Warburton
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P W HochachkaS C Land

❮ Previous
Next ❯

Citations

Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John B Pritchard
Apr 24, 2008·Biological Reviews of the Cambridge Philosophical Society·Glenn J Tattersall, Gordon R Ultsch
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D C JacksonG R Ultsch
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J St-PierreR G Boutilier
Sep 8, 2010·Environmental Toxicology and Chemistry·Robin A Angell, G Douglas Haffner
Nov 27, 2019·The Journal of Experimental Biology·Giulia S Rossi, Patricia A Wright
Feb 10, 2017·Physiological Reviews·Kenneth B Storey, Janet M Storey
Apr 20, 2016·The Journal of Experimental Biology·Joseph M Santin, Lynn K Hartzler
Apr 11, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Yonggang NiuQiang Chen
Oct 14, 2003·The Journal of Experimental Biology·Sarah L MiltonPeter L Lutz
Jun 30, 2009·The Journal of Experimental Biology·Daniel E NayaFrancisco Bozinovic
Jun 30, 2009·The Journal of Experimental Biology·Sara M KayesCraig E Franklin
Jun 17, 1998·Respiration Physiology·P H Donohoe, R G Boutilier
Nov 21, 2021·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Marjoriane de AmaralLuiz Carlos Kucharski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
Donald C Jackson, G R Ultsch
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
J St-PierreR G Boutilier
© 2022 Meta ULC. All rights reserved