PMID: 9166026Apr 1, 1997Paper

Respiratory morbidity from lymphocytic interstitial pneumonitis (LIP) in vertically acquired HIV infection

Archives of Disease in Childhood
M SharlandF Holland

Abstract

The aim of the study was to define the respiratory morbidity caused by lymphocytic interstitial pneumonitis (LIP) in children with vertically acquired HIV infection. A retrospective case note review was performed on 95 children attending three London hospitals. Clinical and radiological evidence of LIP, acute lower respiratory tract infections, and chronic lung disease was obtained using a structured protocol. A diagnosis of LIP had been made in 33%, and an acute admission due to acute lower respiratory tract infection had occurred in 42% of all children (despite 99% taking regular cotrimoxazole prophylaxis). Admission rates because of acute lower respiratory tract infection were significantly higher in the LIP group (0.38 admissions/child year) than in the non-LIP group (0.17 admissions/child year) (p = 0.0002). Encapsulated bacteria (Streptococcus pneumoniae, Haemophilus influenzae) were most frequently isolated. Improved methods of prevention of acute lower respiratory tract infection may help to reduce the severe respiratory morbidity seen in children with LIP and HIV infection.

Citations

May 8, 2000·Indian Journal of Pediatrics·M D Khare, M Sharland
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynne M MofensonCathy Wilfert
Apr 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rashida A FerrandElizabeth L Corbett
Apr 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Diane Gray
Feb 21, 2013·Current Opinion in Pulmonary Medicine·Santino Capocci, Marc Lipman
Jul 9, 2004·HIV Medicine·M SharlandUNKNOWN PENTA Steering Committee
Jan 11, 2014·The Lancet Infectious Diseases·Elizabeth D LowenthalRashida A Ferrand
Mar 5, 2015·Paediatric Respiratory Reviews·Richard D PitcherHeather J Zar
Apr 22, 2004·The Journal of Allergy and Clinical Immunology·Filiz O SeeborgWilliam T Shearer
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·Thandie MwalukomoJamie Rylance
May 9, 2002·British Medical Bulletin·Stephen M Graham, Diana M Gibb
Aug 28, 2007·Pediatric Pulmonology·David M BermanCharles Mitchell
May 14, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Grace McHughRashida A Ferrand

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