Respiratory mortality of childhood, adolescent and young adult cancer survivors.

Thorax
Miranda M FidlerBritish Childhood Cancer Survivor Study (BCCSS) Steering Group

Abstract

Exposure to radiation and/or chemotherapy during cancer treatment can compromise respiratory function. We investigated the risk of long-term respiratory mortality among 5-year cancer survivors diagnosed before age 40 years using the British Childhood Cancer Survivor Study (BCCSS) and Teenage and Young Adult Cancer Survivor Study (TYACSS). The BCCSS comprises 34 489 cancer survivors diagnosed before 15 years from 1940 to 2006 in Great Britain. The TYACSS includes 200 945 cancer survivors diagnosed between 15 years and 39 years from 1971 to 2006 in England and Wales. Standardised mortality ratios and absolute excess risks were used. Overall, 164 and 1079 respiratory deaths were observed in the BCCSS and TYACSS cohorts respectively, which was 6.8 (95% CI 5.8 to 7.9) and 1.7 (95% CI 1.6 to 1.8) times that expected, but the risks varied substantially by type of respiratory death. Greatest excess numbers of deaths were experienced after central nervous system (CNS) tumours in the BCCSS and after lung cancer, leukaemia, head and neck cancer and CNS tumours in the TYACSS. The excess number of respiratory deaths increased with increasing attained age, with seven (95% CI 2.4 to 11.3) excess deaths observed among those aged 50+ years in t...Continue Reading

References

Jun 24, 1978·British Medical Journal·P L GoldinerW S Howland
Oct 1, 1975·Chest·J G Bartlett, S L Gorbach
Feb 1, 1991·Mayo Clinic Proceedings·T S IngrassiaE C Rosenow
Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R I JakackiJ C Allen
Sep 1, 1993·American Journal of Public Health·C H RubinP J Seligman
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE M Eatock
Dec 10, 1999·Quality Assurance : QA·R Lasala, R Rizzello
Feb 15, 2001·Archives of Internal Medicine·A E Smith Sehdev, G M Hutchins
Nov 20, 2002·British Journal of Cancer·J M BirchR J Q McNally
Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen M EmmonsFrederick P Li
Mar 18, 2006·Cancer·Ronald D BarrJillian M Birch
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE Steliarova-Foucher
Sep 25, 2008·Journal of the National Cancer Institute·Ann C MertensYutaka Yasui
Nov 27, 2008·British Journal of Cancer·L FernUNKNOWN National Cancer Research Institute (NCRI) Teenage and Young Adult Clinical Studies Development Group
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen M EmmonsFrederick P Li
Feb 7, 2009·The European Respiratory Journal·R P YoungG D Gamble
Mar 19, 2011·Chest·Tseng-Tien HuangKirsten K Ness
Jun 13, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·David H BrewsterW Hamish Wallace
Jan 24, 2014·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Kinjal DoshiJanet Deatrick
Aug 12, 2014·International Journal of Cancer. Journal International Du Cancer·Andreina E KeroPäivi M Lähteenmäki
Jun 13, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Charlene Treanor, Michael Donnelly
Oct 21, 2015·International Archives of Occupational and Environmental Health·Matthias Möhner
Jan 14, 2016·The New England Journal of Medicine·Gregory T ArmstrongLeslie L Robison
Mar 19, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Salome ChristenGisela Michel
Sep 3, 2016·BMJ : British Medical Journal·Miranda M FidlerUNKNOWN British Childhood Cancer Survivor Study Steering Group
Oct 22, 2016·Journal of Adolescent and Young Adult Oncology·Sapna KaulAnne C Kirchhoff

❮ Previous
Next ❯

Citations

Mar 1, 2019·Pediatric Blood & Cancer·Miranda M FidlerPaul C Nathan
Dec 15, 2018·International Journal of Cancer. Journal International Du Cancer·Lesley SmithRichard G Feltbower
May 29, 2020·Cancer Epidemiology·Friederike ErdmannJeanette Falck Winther
Jun 26, 2021·The Lancet. Haematology·Liv Andrés-JensenUNKNOWN Ponte di Legno Severe Toxicity Working Group

❮ Previous
Next ❯

Software Mentioned

Stata

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.