Respiratory Motion Management in PET/CT: Applications and Clinical Usefulness

Current Radiopharmaceuticals
Luca GuerraCinzia Crivellaro

Abstract

Breathing movement can introduce heavy bias in both image quality and quantitation in PET/CT. The aim of this paper is a review of the literature to evaluate the benefit of respiratory gating in terms of image quality, quantification and lesion detectability. A review of the literature published in the last 10 years and dealing with gated PET/CT technique has been performed, focusing on improvement in quantification, lesion detectability and diagnostic accuracy in neoplastic lesion. In addition, the improvement in the definition of radiotherapy planning has been evaluated. There is a consistent increase of the Standardized Uptake Value (SUV) in gated PET images when compared to ungated ones, particularly for lesions located in liver and in lung. Respiratory gating can also increase sensitivity, specificity and accuracy of PET/CT. Gated PET/CT can be used for radiation therapy planning, reducing the uncertainty in target definition, optimizing the volume to be treated and reducing the possibility of "missing" during the dose delivery. Moreover, new technologies, able to define the movement of lesions and organs directly from the PET sinogram, can solve some problems that currently are limiting the clinical use of gated PET/CT (i...Continue Reading

Citations

Feb 7, 2018·Medical Physics·Adam KesnerTinsu Pan
Aug 13, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Adam Leon Kesner
Jan 11, 2019·EJNMMI Physics·Adam KesnerClaudia Kuntner
Feb 25, 2021·Nuclear Medicine Communications·Jung-Soo KimHyung-Jin Yang
Mar 19, 2020·Current Radiopharmaceuticals·Cinzia Crivellaro, Luca Guerra
Jun 9, 2021·Physics in Medicine and Biology·Andre Z Kyme, Roger R Fulton

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