Respiratory movements alter the generation of prostacyclin and thromboxane A2 in isolated rat lungs: the influence of arachidonic acid-pathway inhibitors on the ratio between pulmonary prostacyclin and thromboxane A2

Prostaglandins
R KorbutT Eling

Abstract

The influence of hyperventilation on the spontaneous generation of prostacyclin and thromboxane A2 by isolated rat lungs was studied. Both prostacyclin and thromboxane A2, as measured by RIA of their stable end-products, 6-oxo-PGF1 alpha and TXB2 respectively, were continuously released into the perfusate. However, the concentration of prostacyclin in the perfusate was higher than thromboxane A2. Under normal ventilation at a rate 40-50 breaths/min, the ratio between these two compounds was 5:1. Increasing the rate of respiration to 100 breaths/min preferentially stimulated the release of prostacyclin. During hyperventilation-stimulated release of prostacyclin and thromboxane A2. Hydroperoxy-fatty acids and tranylcypromine inhibited only the release of prostacyclin but did not affect the generation of thromboxane A2. Our findings confirm that the lung generates prostacyclin predominantly, and provide direct evidence that respiratory movements are involved in generation of pulmonary prostacyclin and thromboxane A2.

References

Jun 29, 1978·Nature·S MoncadaJ R Vane
Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
Apr 1, 1977·Prostaglandins·S MoncadaP Needleman
Nov 1, 1977·Acta Physiologica Scandinavica·J Svensson, B B Fredholm
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Apr 30, 1971·Annals of the New York Academy of Sciences·P Piper, J Vane
Oct 1, 1966·Journal of Gerontology·D Harman, L H Piette
Feb 5, 1971·Science·B M JaffeC W Parker
Mar 1, 1971·The British Journal of Surgery·E M BerryH Wyllie

❮ Previous
Next ❯

Citations

May 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M J GirottiT R Todd
Aug 1, 1981·Prostaglandins·A EdlundA Wennmalm
Jan 1, 1982·Prostaglandins·R KorbutT Eling
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·A N von BethmannS Uhlig
Jul 1, 1987·The American Review of Respiratory Disease·N F VoelkelJ Haynes
Apr 1, 1984·Environmental Health Perspectives·T E Eling, A I Ally
Aug 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M J VassarJ W Holcroft
Jan 1, 1983·Biochemical Pharmacology·K V HonnB F Sloane
Jan 1, 1983·Drug Metabolism Reviews·T ElingK Sivarajah
Dec 19, 2012·Clinical Biochemistry·Arun NarayanankuttyLuis M Teran
Oct 1, 1984·British Journal of Pharmacology·P G Hellewell, J D Pearson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.