PMID: 9163634May 1, 1997Paper

Respiratory muscle function and control of breathing in patients with acromegaly

The European Respiratory Journal
I IandelliG Scano

Abstract

Increase in lung size has been described in acromegalic patients, but data on respiratory muscle function and control of breathing are relatively scarce. Lung volumes, arterial blood gas tensions, and respiratory muscle strength and activation during chemical stimulation were investigated in a group of 10 patients with acromegaly, and compared with age- and sex-matched normal controls. Inspiratory muscle force was evaluated by measuring pleural (Ppl,sn) and transdiaphragmatic (Pdi,sn) pressures during maximal sniffs. Dynamic pleural pressure swing (Ppl,sw) was expressed both as absolute value and as percentage of Ppl,sn. Expiratory muscle force was assessed in terms of maximal expiratory pressure (MEP). In 8 of the 10 patients, ventilatory and respiratory muscle responses to hyperoxic progressive hypercapnia and to isocapnic progressive hypoxia were also evaluated. Large lungs, defined as total lung capacity (TLC) greater than predicted (above 95% confidence limits), were found in five patients. Inspiratory or expiratory muscle force was below normal limits in all but three patients. During unstimulated tidal breathing, respiratory frequency (fR) and mean inspiratory flow (tidal volume/inspiratory time (VT/tI)) were greater, wh...Continue Reading

Citations

Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·F García-RíoJ Villamor
Nov 14, 2013·Multidisciplinary Respiratory Medicine·Gustavo Bittencourt CamiloAgnaldo José Lopes
Dec 10, 2015·São Paulo Medical Journal = Revista Paulista De Medicina·Marcelo Palmeira RodriguesLuiz Augusto Casulari
Jul 7, 2020·Middle East Journal of Digestive Diseases·Delara GholamipoorMehrnaz Asadi Gharabaghi
Feb 11, 2004·Endocrine Reviews·Annamaria ColaoGaetano Lombardi
Feb 23, 2017·Pituitary·Rosario PivonelloAnnamaria Colao
Nov 1, 2015·Expert Review of Endocrinology & Metabolism·Ferdinand Roelfsema, Gerrit van den Berg

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