PMID: 9543350Jun 6, 1998Paper

Respiratory muscle injury in animal models and humans

Molecular and Cellular Biochemistry
W D Reid, N A MacGowan

Abstract

Respiratory muscle injury may result from excessive loading due to a decrease in respiratory muscle strength, an increase in the work of breathing, or an increase in the rate of ventilation. Other conditions such as hypoxemia, hypercapnia, aging, decreased nutrition, and immobilization may potentiate respiratory muscle injury. Respiratory muscle injury has been shown in animal models using direct muscle or phrenic nerve stimulation, acute inspiratory resistive loading, tracheal banding, corticosteroids, phrenic nerve section, and the mdx mouse. Although numerous examples of diaphragm injury have been shown in animal models, evidence in humans is sparse. Potential mechanisms which may contribute to respiratory muscle injury include high levels of intracellular calcium-activated degradative enzymes, non-uniformity of stresses and strains, plasma membrane disruptions, and activation of the inflammatory process.

Citations

Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A B WilliamsP O Hasselgren
Feb 2, 2006·Respiration; International Review of Thoracic Diseases·J H WijnhovenP N R Dekhuijzen
Sep 22, 2007·Critical Care Medicine·Michael MenconiPer-Olof Hasselgren
Sep 1, 2007·Medicine and Science in Sports and Exercise·Brent A BakerRobert G Cutlip
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P O Hasselgren
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·W D Reid, A N Belcastro
Jan 5, 2001·Annals of Surgery·P O Hasselgren, J E Fischer
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Michael I LewisArthur H Cohen
Jun 14, 2005·European Journal of Clinical Investigation·G A RothH J Ankersmit
Mar 29, 2014·Respiratory Research·Marie-Eve ThériaultRichard Debigaré
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·M Orozco-LeviJ Gea
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G LuoP O Hasselgren
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Wulf Dröge
Aug 4, 2007·Journal of Applied Physiology·Michael I LewisRichard Casaburi
Jul 6, 2010·European Journal of Applied Physiology·T van WesselR T Jaspers
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Ira J SmithPer-Olof Hasselgren
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·N A MacgowanW D Reid
Aug 2, 2012·Ultrastructural Pathology·Mauricio Orozco-LeviJoaquim Gea
Dec 16, 2003·The Journal of Physiology·Jeremy A SimpsonSteve Iscoe
Jan 10, 2002·Biochemical and Biophysical Research Communications·Per-Olof HasselgrenJoshua Mammen
Jul 31, 2002·Biochemical and Biophysical Research Communications·Curtis J WrayPer Olof Hasselgren
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
Feb 5, 2004·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·William T Stauber
Aug 30, 2005·The International Journal of Biochemistry & Cell Biology·Per-Olof HasselgrenAmy Evenson
Jul 30, 2005·The International Journal of Biochemistry & Cell Biology·Amy R EvensonPer-Olof Hasselgren

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