Respiratory pre-motor control of hypoglossal motoneurons in the rat

Neuroscience
John H PeeverJ Duffin

Abstract

The goal of this study was to determine the origin and transmission pathway of respiratory drive to hypoglossal motoneurons. First we recorded intracellularly from 28 antidromically activated inspiratory hypoglossal motoneurons (resting membrane potential, -50+/-3 mV), and found that injection of chloride ions had no discernible effect on the shape of their membrane potential trajectories. We concluded that the membrane potential trajectories of these hypoglossal motoneurons were determined primarily by inspiratory excitation. To determine the origin of this excitation we cross-correlated the extracellular discharge of medullary inspiratory neurons, including those in the hypoglossal motor nucleus, with the hypoglossal nerve discharge. We found 27 inspiratory neurons within the hypoglossal motor nucleus that were not antidromically activated from the ipsilateral hypoglossal nerve; their cross-correlograms featured either central peaks (1.7+/-0.2 ms) alone (n=14; 39%), or central peaks (1.3+/-0.2 ms) followed by troughs (1.3+/-0.1 ms) at short latencies (1.1+/-0.4 ms) (n=13; 36%), and suggest that these neurons are hypoglossal interneurons. We recorded from 238 inspiratory neurons throughout the rest of the medulla; the cross-co...Continue Reading

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Citations

May 28, 2005·Respiratory Physiology & Neurobiology·Christian GestreauArmand Louis Bianchi
Jul 11, 2003·Respiratory Physiology & Neurobiology·Mary BehanGordon S Mitchell
Aug 5, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Richard L Horner
Sep 1, 2012·Journal of Applied Physiology·Kun-Ze LeeJi-Chuu Hwang
Sep 6, 2008·Journal of Applied Physiology·Denys V VolginLeszek Kubin
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Aug 15, 2009·Respiratory Research·Frédéric SérièsThomas Similowski
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Jul 31, 2007·Respiratory Physiology & Neurobiology·Jane E Butler
Feb 8, 2005·The Journal of Physiology·Robert B FogelRobert J Pierce
Nov 14, 2006·Experimental Physiology·Safraaz Mahamed, Gordon S Mitchell
Jul 28, 2010·The Journal of Physiology·Fernando MonteroBernardo Moreno-López
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Jun 14, 2019·Frontiers in Molecular Neuroscience·Carolina RozaJavier Márquez
Oct 21, 2006·Journal of Applied Physiology·Julian P SaboiskyJane E Butler

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