Respiratory properties of blood in the harbor porpoise, Phocoena phocoena

The Journal of Experimental Biology
Lisette B SoegaardFrank B Jensen

Abstract

Harbor porpoises are active divers that exchange O(2) and CO(2) with the environment during a fast single breath upon surfacing. We investigated blood O(2)-transporting properties, buffer characteristics, Cl(-) transport via the erythrocyte anion exchanger (AE1), circulating nitric oxide metabolites and hemoglobin nitrite reduction in harbor porpoises with the aim to evaluate traits that are adaptive for diving behavior. Blood O(2) affinity was higher in harbor porpoises than in similar sized terrestrial mammals, as supported by our parallel recordings of O(2) equilibria in sheep and pig blood. Further, O(2) affinity tended to increase with increasing body mass. A high O(2) affinity favors O(2) extraction from the lungs, but a normal Bohr effect (ΔlogP(50)/ΔpH=-0.46) gradually lowers O(2) affinity during dives (where CO(2) accumulates) to assist O(2) off-loading to perfused tissues. The true plasma non-bicarbonate buffer value was moderately higher than in terrestrial mammals and increased upon deoxygenation. Plasma bicarbonate was also relatively high, contributing to increase the overall buffer capacity. The apparent Cl(-) permeability of harbor porpoise erythrocytes was similar to the human value at 37°C, showing absence of ...Continue Reading

References

Apr 1, 1977·The Journal of Physiology·J Brahm, J O Wieth
Sep 1, 1977·The Journal of General Physiology·J Brahm
Nov 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P Scheid, M Meyer
Aug 1, 1987·Environmental Health Perspectives·H Kosaka, I Tyuma
May 1, 1986·Respiration Physiology·D C Willford, E P Hill
Oct 1, 1971·Journal of Applied Physiology·J N Cameron
Dec 1, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J O WiethC L Borders
Dec 1, 1983·Respiration Physiology·G K Snyder
Jan 1, 1981·Annual Review of Physiology·G L KooymanR W Davis
Oct 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·F MoragaA J Llanos
Jul 1, 1997·Physiological Reviews·P J Butler, D R Jones
Mar 9, 2000·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J Z ReedR G Boutilier
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R G BoutilierM A Fedak
Oct 30, 2003·Free Radical Biology & Medicine·Petra KleinbongardMalte Kelm
Nov 5, 2003·Nature Medicine·Kenyatta CosbyMark T Gladwin
Dec 14, 2004·Journal of Applied Physiology·Rohit MoudgilStephen L Archer
Jul 6, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·P J PonganisE A Baranov
Feb 27, 2007·The Journal of Biological Chemistry·Rozalina GrubinaMark T Gladwin
Jun 15, 2007·Cardiovascular Research·Cameron DezfulianMark T Gladwin
Jul 20, 2007·Acta Physiologica·F J LarsenB Ekblom
Nov 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·S C ErzurumC M Beall
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Jul 4, 2008·Blood·Mark T Gladwin, Daniel B Kim-Shapiro
Feb 27, 2009·Basic Research in Cardiology·Sruti Shiva, Mark T Gladwin
Mar 3, 2009·Biochimica Et Biophysica Acta·Frank B Jensen
Jul 31, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica U MeirPaul J Ponganis
Oct 6, 2009·The Journal of Experimental Biology·Jessica U Meir, Paul J Ponganis
Nov 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Thomas E IngramPhilip E James
Mar 26, 2010·Physiological and Biochemical Zoology : PBZ·Jessica U Meir, Paul J Ponganis
Oct 19, 2010·The Journal of Experimental Biology·Marie N Hansen, Frank B Jensen
Nov 30, 2010·The Journal of Experimental Biology·Jay F StorzZachary A Cheviron
Feb 3, 2011·Cell Metabolism·Filip J LarsenEddie Weitzberg
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Guro K SandvikFrank B Jensen
Dec 17, 2011·Respiratory Physiology & Neurobiology·Nina K IversenTobias Wang

❮ Previous
Next ❯

Citations

Sep 3, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Aleksandra MazurFrancois Guerrero
Jan 23, 2017·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Frank B JensenTobias Wang
Sep 14, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bethany L WilliamsJon P Costanzo
Mar 3, 2015·Physiology·Angela Fago, Frank B Jensen
Mar 9, 2013·The Journal of Experimental Biology·Jesper Brahm
Jun 14, 2012·The Journal of Experimental Biology·Signe Helbo, Angela Fago
May 20, 2015·The Journal of Experimental Biology·Traver J Wright, Randall W Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.